Objective:　To　optimum　the　chelation　technology　of　whey　protein　peptides　with　calcium,　based　on　single　factor　tests,　the　response　surface　method　was　used　to　investigate　optimized　technological　conditions.　Finally,　the　optimum　level　was　established　and　whey　protein　peptide-calcium　chelation　was　obtained,　which　can　explore　the　new　function　of　whey　proteins　and　metal　ion　chelate　compound　and　provide　a　new　type　of　health　food.　Methods:　Whey　protein　was　hy-drolysed　by　protemax　and　flavourzyme,　then　process　optimization　for　chelating　reaction　between　whey　protein　peptides　and　calcium　was　conducted　using　response　surface　method.　After　this,　the　characters　of　chelate　compounds　were　detected　by　infrared　spectrometry　and　fluorescent　spectrometry.　Results:　The　optimum　process　parameters　for　the　whey　protein　peptides-calcium　chelation;　the　calcium　was　added　in　the　form　of　liquid,　whey　protein　peptide　and　CaCl2　ratio　of　24:1　(m/m),　whey　protein　peptide　concentration　3.5%,　reaction　time　20　min,　reaction　temperature　30°C,　pH7.0;　the　whey　protein　chelated　calcium　was　characterized　by　infrared　spectrometry　and　fluorescent　spectrometry,　the　results　showed　that　the　whey　protein　peptides　had　successfully　chelated　onto　calcium.　Conclusion;　The　whey　protein　peptides　obtained　after　enzy-matic　hydrolysis　have　successfully　chelated　onto　calcium　in　the　CaCl2;　The　chelates　provide　new　opportunities　for　whey　protein　composite　products＇　production　and　development.