Natural　2-phenylethanol　is　a　high　value　aroma　chemical　and　can　be　produced　from　l-phenylalanine　via　Ehrlich　pathway　by　yeasts.　Due　to　serious　product　inhibition,　the　space-time　yield　is　usually　low.　A　continuous　approach　using　macroporous　resin　as　in　situ　adsorbent　made　it　possible　that　the　quantity　and　viability　of　the　cells　were　improved　simultaneously.　With　Saccharomyces　cerevisiae　sp.　strain　R-UV3,　the　highest　space-time　yield　of　0.90gL-1h-1　reported　so　far　was　obtained.　©　2011　Elsevier　Inc.