Molecular cloning and sequence analysis of the sisomicin biosynthetic gene cluster from Micromonospora inyoensis - Details

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Abstract：

Micromonospora　inyoensis　produces　sisomicin　(Sm),　an　aminoglycoside　antibiotic.　The　gene　cluster　of　sisomicin　biosynthesis　spanning　ca.　47　kb　consists　of　37　ORFs　encoding　various　proteins　for　sisomicin　biosynthesis,　regulation,　resistance　and　transport.　The　comparative　genetic　studies　on　the　biosynthetic　genes　of　sisomicin　and　gentamicin　(Gm)　reveal　a　similar　biosynthetic　route　and　provide　a　framework　for　the　future　biosynthetic　studies.　©　2008　Springer　Science+Business　Media　B.V.

Keyword：

Biochemistry Biosynthesis Clone cells Cloning Genes

Community：

[ 1 ] [Hong, Wun-Rong]College of Biological Science and Technology, Fuzhou University, 523 Gongye Rd, Fuzhou City, Fujian, China
[ 2 ] [Ge, Mei]Shanghai Health Creation Center for Biopharmaceuticals R and D, 200 Newton Rd, Shanghai, China
[ 3 ] [Zeng, Zhi-Hong]College of Biological Science and Technology, Fuzhou University, 523 Gongye Rd, Fuzhou City, Fujian, China
[ 4 ] [Zhu, Li]Shanghai Health Creation Center for Biopharmaceuticals R and D, 200 Newton Rd, Shanghai, China
[ 5 ] [Luo, Min-Yu]Shanghai Health Creation Center for Biopharmaceuticals R and D, 200 Newton Rd, Shanghai, China
[ 6 ] [Shao, Lei]Shanghai Institute of Pharmaceutical Industry, 1320 West Beijing Rd, Shanghai, China
[ 7 ] [Chen, Dai-Jie]Shanghai Institute of Pharmaceutical Industry, 1320 West Beijing Rd, Shanghai, China

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Source ：

Biotechnology Letters

ISSN： 0141-5492

Year： 2009

Issue： 3

Volume： 31

Page： 449-455

1 . 6 3 6

JCR@2009

2 . 0 0 0

JCR@2023

JCR Journal Grade：3

CAS Journal Grade：1

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 4

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