Enlightened　by　biological　immune　system,　this　paper　applies　the　idea　of　vaccine　extraction　and　vaccination,　this　paper　proposes　quantum-behaved　particle　swarm　optimization　with　immunity　algorithm　(IQPSO).　In　this　algorithm,　vaccination　can　guide　the　particles　to　evolve　towards　much　better　direction.　Experiments　show　that　attribute　reduction　based　on　IQPSO　algorithm　achieve　much　better　result　both　in　convergence　speed　and　optimization　capabilities　in　comparison　with　other　algorithms,　such　as　Hu　algorithm,　particle　swarm　optimization,　and　quantum-behaved　particle　swarm　optimization.