In　order　to　promote　isolated　technique　application　in　multi-story　building　and　reduce　the　disaster　of　earthquake,　the　method　of　establishing　and　choosing　the　models　of　structure,　designing　the　base-isolated　layer　and　the　actual　meaning　of　dynamic　character　are　discussed　in　conjunction　with　Code　for　seismic　design　of　building　(GB50011-2001).　Then　story　shear　models　are　adopted　and　the　data　is　calculated　and　analyzed　through　MATLAB　program,　taking　the　real　engineering　as　an　example.　Base-isolated　structure　will　concentrate　deformation　onto　the　rubber　bearing　layer,　and　the　acceleration　and　interlaminar　shear　of　each　floor　will　decrease.　The　result　shows　that　the　multi-story　building　that　uses　isolated　structure　can　lower　the　earthquake　reaction　effectively,　and　ensure　that　it　can　be　used　normally　in　rare　earthquakes.