As　an　advanced　form　of　Innovation　Cluster　after　the　Fourth　Industrial　Revolution,　Scientific　and　Technological　Industrial　Innovation　Cluster　has　become　an　important　support　to　promote　the　development　of　national　innovation　in　the　future,　and　the　world＇s　advanced　countries　have　optimized　the　development　of　Traditional　Innovation　Cluster　according　to　it.　This　research　introduces　the　development　needs　of　Macao＇s　Traditional　Innovation　Clusters　through　its　innovation　capability　and　innovation　index,　compares　the　advantages　and　disadvantages　of　Innovation　Clusters　and　Industrial　Clusters,　and　discusses　the　future　development　mode　of　Macao＇s　technological　innovation　by　learning　experience　from　the　development　of　South　Korea＇s　Science　and　Technological　Industrial　Clusters.　According　to　South　Korea＇s　experience　and　the　advantages　and　characteristics　of　Macao＇s　regions,　the　construction　should　be　reformed　based　on　the　advantages　of　Industrial　Clusters　and　regional　development　so　as　to　reduce　costs　and　control　the　scale　of　investment.　At　the　same　time,　it＇s　also　vital　to　actively　develop　and　utilize　Hengqin　New　District,　attract　top　scientific　research　institutions　and　talents　from　the　world,　in　which　way　Macao＇s　Science　and　Technology　Industry　Innovation　Cluster　could　be　built.　©　2020　Published　under　licence　by　IOP　Publishing　Ltd.