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author:

Lin, Hungyen (Lin, Hungyen.) [1] | May, Robert K. (May, Robert K..) [2] | Evans, Michael J. (Evans, Michael J..) [3] | Zhong, Shuncong (Zhong, Shuncong.) [4] (Scholars:钟舜聪) | Warr, Ian (Warr, Ian.) [5] | Gladden, Lynn F. (Gladden, Lynn F..) [6] | Shen, Yaochun (Shen, Yaochun.) [7] | Zeitler, J. Axel (Zeitler, J. Axel.) [8]

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EI Scopus

Abstract:

Terahertz in-line sensing was successfully demonstrated previously for measuring the coating thickness of individual pharmaceutical tablets during a production scale film coating process. This paper investigates how this technology can be used to evaluate the impact of changes in the process conditions on the inter-tablet coating thickness distribution. The process changes that were investigated in this study were the removal of the mixing baffles from the coating pan, blockage of one of the spray guns and the addition of uncoated tablet cores to a bed of partially coated tablets. Using the terahertz sensor the coating thickness of more than 20 individual tablets was sampled per minute in situ throughout the coating process. By analysing the resulting variation in coating thickness distribution it was possible to resolve the effect of all these process changes on the coating thickness homogeneity within the batch. © 2013 IEEE.

Keyword:

Coatings Coating techniques Spray guns Terahertz waves Thickness control Thickness measurement

Community:

  • [ 1 ] [Lin, Hungyen]Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, United Kingdom
  • [ 2 ] [May, Robert K.]TeraView Ltd. St. John's Innovation Park, Cambridge CB4 0WS, United Kingdom
  • [ 3 ] [Evans, Michael J.]TeraView Ltd. St. John's Innovation Park, Cambridge CB4 0WS, United Kingdom
  • [ 4 ] [Zhong, Shuncong]School of Mechanical Engineering and Automation, Fuzhou University, Fuzhou 350108, China
  • [ 5 ] [Warr, Ian]Oystar Manesty, Merseyside L34 9JS, United Kingdom
  • [ 6 ] [Gladden, Lynn F.]Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, United Kingdom
  • [ 7 ] [Shen, Yaochun]Department of Electrical Engineering and Electronics, University of Liverpool, Liverpool L69 3GJ, United Kingdom
  • [ 8 ] [Zeitler, J. Axel]Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, United Kingdom

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ISSN: 2162-2027

Year: 2013

Language: English

Cited Count:

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SCOPUS Cited Count: 1

ESI Highly Cited Papers on the List: 0 Unfold All

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Chinese Cited Count:

30 Days PV: 0

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