The　uniform　design　method　is　used　to　arrange　experiment　of　dispersion　polymerization　of　styrene,　butyl　acrylate　and　acryl　acid.　The　stepwise　regression　technique　is　adopted　to　analyze　the　results.　The　mathematical　models　are　built　by　regression　equations　between　the　microsphere　conversion　rate,　the　size　and　its　distribution.　There　are　many　influencing　factors,　such　as,　3　monomer　concentrations,　stabilizer　concentration,　initiator　concentration,　ratio　of　alcohol　and　water,　temperature　established,　and　their　reliabilities　evaluated.　Although　the　predicted　values　from　regression　equation　different　from　the　observed　values　(relative　divergences　less　than　10%),　the　regression　equation　can　be　used　for　designing　particles　and　mechanism　research.　All　above　researches　can　be　used　for　optimizing　dispersion　polymerization　reaction　conditions.　©　(2011)　Trans　Tech　Publications.