Crystal　chemistry　is　the　theory　that　study　the　crystal　structure　at　the　atomic　level.　It　is　a　branch　of　physics　and　chemistry　that　reveals　the　internal　relations　between　the　chemical　composition,　structure　and　properties　of　the　crystal　and　the　related　principles.　The　law　of　constancy　of　angles,　the　zone　law　and　the　Pauling＇s　rules　have　laid　the　foundation　of　crystal　chemistry.　Crystal　structure　and　chemical　composition　are　important　factors　affecting　minerals　flotation　separation,　and　are　also　the　main　research　contents　of　crystal　chemistry.　Crystal　chemistry　has　been　widely　used　in　the　copper　oxide　minerals　flotation,　including　the　study　on　the　minerals　crystal　structure　and　surface　characteristics,　such　as　the　mode　of　occurrence　of　elements,　the　type　of　chemical　bond,　the　polarity　of　ionic　bond,　ion　radius,　solubility　and　copper　ion　exposure　on　the　surface　of　the　mineral.　The　relationship　among　the　copper　oxide　minerals　crystal　structure,　surface　properties　and　copper　oxide　minerals　floatability　and　the　influence　of　collector　and　various　adjusting　agents　on　copper　oxide　minerals　flotation　and　its　mechanism　analysis　are　also　discussed.　Crystal　chemistry　is　one　of　the　important　theoretical　bases　for　minerals　separation,　and　plays　an　important　role　in　minerals　flotation.　The　azurite,　cuprite,　malachite　and　chrysocolla　are　main　copper　oxide　minerals　which　have　industrial　utilization　values.　This　paper　summarized　the　research　contents　of　crystal　chemistry　and　its　application　in　copper　oxide　minerals　flotation,　introduced　the　research　status　of　the　minerals　crystal　structure,　ionic　bond　and　polarization　degree　of　copper　oxide　minerals,　and　the　research　progress　of　surface　properties　and　floatability　of　copper　oxide　minerals.　The　application　of　crystal　chemistry　in　the　study　of　flotation　reagent　action　mechanism　and　flotation　condition　control　were　reviewed,　the　research　directions　of　crystal　chemistry　in　minerals　flotation　were　pointed　out,　including　that　crystal　chemistry　combined　with　tests　and　analysis　technologies　and　a　variety　of　basic　theories　and　disciplines.　Key　learning　points:　(1)　Crystal　structure　and　chemical　composition　are　important　factors　affecting　minerals　flotation　separation,　and　are　also　the　main　research　contents　of　crystal　chemistry.　(2)　The　crystal　structure,　surface　characteristics　and　floatability　of　azurite,　cuprite,　malachite　and　chrysocolla　have　been　studied　extensively.　(3)　Crystal　chemistry　is　widely　used　in　the　research　of　flotation　mechanism　and　flotation　condition　control　of　copper　oxide　minerals.　©　2018,　Science　Press.　All　right　reserved.