Study on ionization constants of alkaloids by linear model with capillary electrophoresis-electrochemical detection - Details

author：

Zhang, L. (Zhang, L..) ^[1] | Chen, G.-N. (Chen, G.-N..) ^[2] | Fang, Y.-Z. (Fang, Y.-Z..) ^[3]

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Scopus PKU CSCD

Abstract：

A　method　based　on　a　linear　model　for　determination　of　the　ionization　constants　(pKa)　of　some　alkaloids　(benzedrine/BZD,　phenylpropanolamine/PPA,　ephedrine/EPD　and　methylephedrine/MEPD)　by　capillary　zone　electrophoresis　with　electrochemistry　detection　has　been　developed.　The　Ka　values　were　obtained　from　the　plots　of　the　reciprocal　of　effective　mobility　against　the　reciprocal　of　concentration　of　sodium　hydroxide.　The　pKa　values　evaluated　by　this　method　were　consistent　with　the　values　by　UV,　and　also　agreeable　to　the　literature　values.　The　proposed　method　was　simple,　quick　and　reliable　for　determination　of　the　ionization　constants　(pKa)　of　alkaloids　simultaneously.

Keyword：

Alkaloid; Capillary electrophoresis; Electrochemical detection; Ionization constant

Community：

[ 1 ] [Zhang, L.]Department of Chemistry, Fuzhou University, Fuzhou 350002, China
[ 2 ] [Chen, G.-N.]Department of Chemistry, Fuzhou University, Fuzhou 350002, China
[ 3 ] [Fang, Y.-Z.]Department of Chemistry, East China Normal University, Shanghai 200062, China

Reprint 's Address：

[Zhang, L.]Department of Chemistry, Fuzhou University, Fuzhou 350002, China

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Source ：

Acta Chimica Sinica

ISSN： 0567-7351

Year： 2004

Issue： 10

Volume： 62

Page： 975-978

0 . 8 9 5

JCR@2004

1 . 7 0 0

JCR@2023

JCR Journal Grade：2

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