Syntheses of metal phthalocyanines and their photoinactivations on cancer cells - Details

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Abstract：

This　paper　reported　the　syntheses　of　amphiphilic　substituted　metal　phthalocyanines　containing　sulfonic　acid　groups　and　phthalimidomethyl　groups　(MPcSP,　M　=　Zn　or　Al(OH),　S　=　-SO3-,　P　=　phthalimidomethyl).　We　have　selected　zinc　phthalocyanine　(Zn-D)　as　the　one　with　better　cell　killing　potential　by　an　in　vitro　cell　survival　assay.　Over　90%　tumor　cells　were　killed　with　10　mg/L　Zn-D,　after　they　were　exposed　to　12　J/cm2　red　light.

Keyword：

Metal phthalocyanic; Photodynamic therapy (PDT); Photosensitizer; Syntheses; Tumor cells

Community：

[ 1 ] [Liu, E.-S.]Department of Chemistry, Institute of Functional Materials, Fuzhou University, Fuzhou 350002, China
[ 2 ] [Dai, Z.-F.]Department of Chemistry, Institute of Functional Materials, Fuzhou University, Fuzhou 350002, China
[ 3 ] [Huang, J.-D.]Department of Chemistry, Institute of Functional Materials, Fuzhou University, Fuzhou 350002, China
[ 4 ] [Chen, N.-S.]Department of Chemistry, Institute of Functional Materials, Fuzhou University, Fuzhou 350002, China
[ 5 ] [Huang, J.-L.]Department of Chemistry, Institute of Functional Materials, Fuzhou University, Fuzhou 350002, China
[ 6 ] [Huang, Z.-Q.]Cancer Pharmacology Research Section, Fujian Medical University, Fuzhou 350004, China
[ 7 ] [Sun, J.-C.]Cancer Pharmacology Research Section, Fujian Medical University, Fuzhou 350004, China

Reprint 's Address：

[Liu, E.-S.]Department of Chemistry, Institute of Functional Materials, Fuzhou University, Fuzhou 350002, China

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Source ：

Acta Biochimica et Biophysica Sinica

ISSN： 0582-9879

Year： 1998

Issue： 1

Volume： 30

Page： 33-34

0 . 1 0 6

JCR@1998

3 . 3 0 0

JCR@2023

JCR Journal Grade：4

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 3

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