Acupoint　electrical　potential　difference　(EPD)　measurement　has　been　proved　to　be　able　to　respond　rapidly　to　the　stimuli　such　as　antioxidant　intervention.　In　this　study,　the　effects　of　infusions　of　green　tea,　oolong　tea,　and　black　tea　on　the　EPD　of　8　human　meridians　(heart　meridian,　liver　meridian,　spleen　meridian,　lung　meridian,　kidney　meridian,　small　intestine　meridian,　gallbladder　meridian　and　stomach　meridian)　were　investigated　by　acupoint　EPD　measurement.　The　antioxidant　activity　in　vitro　and　the　particle　size　distribution　of　three　kinds　of　tea　were　also　determined.　Results　showed　that　the　effect　of　three　kinds　of　tea　soup　on　the　EPD　of　small　intestine　meridians　are　the　most　obvious.　Three　kinds　of　tea　soup　can　produce　physiological　effects,　such　as　hiccups,　intestinal　peristalsis;　and　the　physiological　effects　of　black　tea　is　the　most　obvious　effect.　The　particle　size　of　black　tea　is　the　smallest　and　most　uniform,　and　its　immediate　changes　in　the　EPD　and　the　physiological　effects　are　most　obvious,　revealing　that　the　size　of　the　micelles　in　the　tea　soup　can　affect　its　immediate　body　effect　to　some　extent.　We　formulate　the　hypothesis　that　tea　soup　eliminates　charged　active　species　on　the　intestinal　wall,　thereby　stimulating　contraction　of　intestinal　smooth　muscle　and　then　giving　rise　to　physiological　responses,　such　as　hiccups;　and　tea　soup　relieves　oxidative　stress　in　the　liver　by　the　hepatic　and　biliary　tract;　and　because　of　the　presence　of　human　bio-electricity　network　system,　oxidative　stress　transfer　between　the　liver　and　intestine,　leading　to　the　EPD　changes　in　the　meridians　which　connect　to　various　organs.　©　2018,　Editorial　Office　of　Journal　of　CIFST.　All　right　reserved.