Direct　dehydrogenation　of　isobutane　to　isobutene　has　drawn　extensive　attention　for　synthesizing　various　chemicals.　The　Mo-based　catalysts　hold　promise　as　an　alternative　to　the　toxic　CrOx-And　scarce　Pt-based　catalysts.　However,　the　low　activity　and　rapid　deactivation　of　the　Mo-based　catalysts　greatly　hinder　their　practical　applications.　Herein,　we　demonstrate　a　feasible　approach　toward　the　development　of　efficient　and　non-noble　metal　dehydrogenation　catalysts　based　on　Mo-CT　hybrid　nanowires　calcined　at　different　temperatures.　In　particular,　the　optimal　Mo-C700　catalyst　exhibits　isobutane　consumption　rate　of　3.9　mmol　g-1　h-1　and　isobutene　selectivity　of　73%　with　production　rate　of　2.8　mmol　g-1　h-1.　The　catalyst　maintained　90%　of　its　initial　activity　after　50　h　of　reaction.　Extensive　characterizations　reveal　that　such　prominent　performance　is　well　correlated　with　the　adsorption　abilities　of　isobutane　and　isobutene　and　the　formation　of　IÀ-MoC　species.　In　contrast,　the　generation　of　β-Mo2C　crystalline　phase　during　long-Term　reaction　causes　minor　decline　in　activity.　Compared　to　MoO2　and　β-Mo2C,　IÀ-MoC　plays　a　role　more　likely　in　suppressing　the　cracking　reaction.　This　work　demonstrates　a　feasible　approach　toward　the　development　of　efficient　and　non-noble　metal　dehydrogenation　catalysts.　©　2018　American　Chemical　Society.