Transition-Metal-Free Selective Iodoarylation of Pyrazoles via Heterocyclic Aryliodonium Ylides - Details

author：

Lu, N. (Lu, N..) ^[1] | Huang, L. (Huang, L..) ^[2] | Xie, L. (Xie, L..) ^[3] | Cheng, J. (Cheng, J..) ^[4]

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Abstract：

A　one-pot　transition-metal-free　selective　iodoarylation　of　pyrazoles　with　aryliodine　diacetates　has　been　developed.　The　reaction　proceeds　via　the　generation　of　NH-pyrazole-iodonium　salts　in　situ,　followed　by　sequential　phen/K2CO3-mediated　intermolecular　arylation.　When　the　iodonium　ylide　was　directly　used　as　substrate,　the　difunctionalization　products　could　be　prepared　in　high　yield　under　base-　and　metal-free　conditions.　This　transformation　provides　an　efficient　route　to　high-value　multisubstituted　pyrazole　derivatives　from　simple　and　readily　available　substrates.　©　2018　WILEY-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim

Keyword：

Iodine-mediated reactions; Iodoarylation; One-pot reactions; Pyrazoles; Ylides

Community：

[ 1 ] [Lu, N.]State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 2 ] [Huang, L.]State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 3 ] [Xie, L.]State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 4 ] [Cheng, J.]State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 5 ] [Cheng, J.]State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China

Reprint 's Address：

[Xie, L.]State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou UniversityChina

Email：

xielili@fzu.edu.cn

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Source ：

European Journal of Organic Chemistry

ISSN： 1434-193X

Year： 2018

Issue： 26

Volume： 2018

Page： 3437-3443

3 . 0 2 9

JCR@2018

2 . 5 0 0

JCR@2023

ESI HC Threshold：209

JCR Journal Grade：2

CAS Journal Grade：3

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 11

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 0

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