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author：

Huang, G. (Huang, G..) [1] | Liu, R. (Liu, R..) [2] | Hu, Y. (Hu, Y..) [3] | Li, S.-H. (Li, S.-H..) [4] | Wu, Y. (Wu, Y..) [5] | Qiu, Y. (Qiu, Y..) [6] | Li, J. (Li, J..) [7] | Yang, H.-H. (Yang, H.-H..) [8]

Indexed by：

Scopus CSCD

Abstract：

The　development　of　stimuli-responsive　theranostic　platforms　is　of　great　demand　for　efficient　cancer　treatment　because　they　can　enhance　diagnostic　specificity　and　sensitivity.　In　this　work,　we　report　a　pH-responsive　theranostic　nanoplatform　based　on　FeOOH　clusters　loaded　mesoporous　silica　nanoparticles　(Fe@MSNs).　The　as-synthesized　Fe@MSNs　possess　activatable　T1　magnetic　resonance　imaging　(MRI)　performance　that　can　respond　to　the　acidic　microenvironment　of　solid　tumor　to　turn　on　T1　singals　by　releasing　paramagnetic　Fe3+　ions.　The　Fe@MSNs　are　biocompatible　without　appreciable　cytotoxicity.　Moreover,　the　unique　mesoporous　structure　endows　the　Fe@MSNs　with　significant　advantages　to　effectively　deliver　chemotherapeutic　drug　for　inhibiting　the　growth　of　solid　tumor.　We　believe　that　this　novel　pH-responsive　theranostic　nanoplatform　holds　great　promise　in　cancer　treatment.　©　2018,　Science　China　Press　and　Springer-Verlag　GmbH　Germany,　part　of　Springer　Nature.

Keyword：

cancer diagnosis; cancer therapy; magnetic resonance imaging; mesoporous silica nanoparticles; pH-response

Community：

  • [ 1 ] [Huang, G.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, China
  • [ 2 ] [Liu, R.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, China
  • [ 3 ] [Hu, Y.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, China
  • [ 4 ] [Li, S.-H.]Key Laboratory for Analytical Science of Food Safety and Biology, Ministry of Education, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350116, China
  • [ 5 ] [Wu, Y.]Key Laboratory for Analytical Science of Food Safety and Biology, Ministry of Education, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350116, China
  • [ 6 ] [Qiu, Y.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, China
  • [ 7 ] [Li, J.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, China
  • [ 8 ] [Yang, H.-H.]Key Laboratory for Analytical Science of Food Safety and Biology, Ministry of Education, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350116, China

Reprint 's Address：

  • [Li, J.]College of Biological Science and Engineering, Fuzhou UniversityChina

Email：


lijingying@fzu.edu.cn
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Source ：

Science China Chemistry

ISSN： 1674-7291

Year： 2018

Issue： 7

Volume： 61

Page： 806-811

6 . 0 8 5

JCR@2018

1 0 . 4 0 0

JCR@2023

ESI HC Threshold：209

JCR Journal Grade：1

CAS Journal Grade：3

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 23

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 0

Affiliated Colleges：

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