Scavenger　receptors　(SRs)　play　critical　roles　in　various　physiological　and　pathological　pathways.　One　of　them,　CD163,　is　a　multifunctional　endocytic　receptor　and　is　characterized　by　a　long-range　scavenger　receptor　cysteine-rich　(SRCR)　repeat.　However,　the　structural　and　functional　details　of　this　long-range　SRCR　repeat　have　not　yet　been　elucidated.　In　this　study,　the　CD163　long-range　SRCR　repeat　was　expressed　in　Drosophila　Schneider　2　cells.　The　recombinant　protein　was　homogeneous　after　purification　by　metal-affinity,　cation-exchange　and　size-exclusion　chromatography.　Single　crystals　were　obtained　using　20%　PEG　4000,　0.15　M　potassium　sodium　tartrate　tetrahydrate　pH　8.5　and　diffracted　to　3.30　Å　resolution.　As　the　first　view　of　a　long-range　SRCR　repeat,　this　work　lays　the　structural　basis　for　a　deep　understanding　of　SRs　and　their　multiple　functions.The　CD163　long-range　scavenger　receptor　cysteine-rich　(SRCR)　repeat　was　prepared　in　a　Drosophila　system　and　was　crystallized　using　20%　PEG　4000,　0.15　M　potassium　sodium　tartrate　tetrahydrate　pH　8.5.　X-ray　crystallographic　characterization　of　this　long-range　SRCR　repeat　will　provide　structural　and　functional　information　for　the　scavenger　receptor　superfamily.　©　International　Union　of　Crystallography,　2018.