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author：

Lin, L.-S. (Lin, L.-S..) [1] | Song, J. (Song, J..) [2] | Song, L. (Song, L..) [3] | Ke, K. (Ke, K..) [4] | Liu, Y. (Liu, Y..) [5] | Zhou, Z. (Zhou, Z..) [6] | Shen, Z. (Shen, Z..) [7] | Li, J. (Li, J..) [8] | Yang, Z. (Yang, Z..) [9] | Tang, W. (Tang, W..) [10] | Niu, G. (Niu, G..) [11] | Yang, H.-H. (Yang, H.-H..) [12] | Chen, X. (Chen, X..) [13]

Indexed by：

Scopus

Abstract：

Chemodynamic　therapy　(CDT)　utilizes　iron-initiated　Fenton　chemistry　to　destroy　tumor　cells　by　converting　endogenous　H2O2　into　the　highly　toxic　hydroxyl　radical　(.OH).　There　is　a　paucity　of　Fenton-like　metal-based　CDT　agents.　Intracellular　glutathione　(GSH)　with　.OH　scavenging　ability　greatly　reduces　CDT　efficacy.　A　self-reinforcing　CDT　nanoagent　based　on　MnO2　is　reported　that　has　both　Fenton-like　Mn2+　delivery　and　GSH　depletion　properties.　In　the　presence　of　HCO3−,　which　is　abundant　in　the　physiological　medium,　Mn2+　exerts　Fenton-like　activity　to　generate　.OH　from　H2O2.　Upon　uptake　of　MnO2-coated　mesoporous　silica　nanoparticles　(MS@MnO2　NPs)　by　cancer　cells,　the　MnO2　shell　undergoes　a　redox　reaction　with　GSH　to　form　glutathione　disulfide　and　Mn2+,　resulting　in　GSH　depletion-enhanced　CDT.　This,　together　with　the　GSH-activated　MRI　contrast　effect　and　dissociation　of　MnO2,　allows　MS@MnO2　NPs　to　achieve　MRI-monitored　chemo–chemodynamic　combination　therapy.　©　2018　Wiley-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim

Keyword：

antitumor agents; Fenton-like reaction; glutathione; imaging agents; manganese dioxide

Community：

  • [ 1 ] [Lin, L.-S.]MOE key laboratory for analytical science of food safety and biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 2 ] [Lin, L.-S.]Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, United States
  • [ 3 ] [Song, J.]MOE key laboratory for analytical science of food safety and biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 4 ] [Song, J.]Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, United States
  • [ 5 ] [Song, L.]MOE key laboratory for analytical science of food safety and biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 6 ] [Ke, K.]MOE key laboratory for analytical science of food safety and biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 7 ] [Liu, Y.]Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, United States
  • [ 8 ] [Zhou, Z.]Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, United States
  • [ 9 ] [Shen, Z.]Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, United States
  • [ 10 ] [Li, J.]MOE key laboratory for analytical science of food safety and biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 11 ] [Yang, Z.]Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, United States
  • [ 12 ] [Tang, W.]Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, United States
  • [ 13 ] [Niu, G.]Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, United States
  • [ 14 ] [Yang, H.-H.]MOE key laboratory for analytical science of food safety and biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 15 ] [Chen, X.]Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, United States

Reprint 's Address：

  • [Yang, H.-H.]MOE key laboratory for analytical science of food safety and biology, College of Chemistry, Fuzhou UniversityChina

Email：


hhyang@fzu.edu.cn
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Source ：

Angewandte Chemie - International Edition

ISSN： 1433-7851

Year： 2018

Issue： 18

Volume： 57

Page： 4902-4906

1 2 . 2 5 7

JCR@2018

1 6 . 1 0 0

JCR@2023

ESI HC Threshold：209

JCR Journal Grade：1

CAS Journal Grade：2

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 0

Affiliated Colleges：

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