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author：

Li, J. (Li, J..) [1] | Qiu, L. (Qiu, L..) [2] | Xie, S. (Xie, S..) [3] | Zhang, J. (Zhang, J..) [4] | Zhang, L. (Zhang, L..) [5] | Liu, H. (Liu, H..) [6] | Zhang, X. (Zhang, X..) [8] | Tan, W. (Tan, W..) [9]

Indexed by：

Scopus CSCD

Abstract：

Drug　administration　customized　to　individual　cells　could　intrinsically　address　cancer　heterogeneity　and　provide　a　safe　and　effective　method　for　delivering　personalized　treatment.　To　accomplish　this,　we　developed　a　smart　nanodrug　delivery　system　characterized　by　cancer　cell-targeted　drug　delivery　and　intracellular　biomarker-responsive　drug　activation.　This　system　was　composed　of　a　long-nicked　DNA　duplex　formed　by　tandem　hybridization　of　two　extended　antisense　oligonucleotides　whose　ends　were　separately　blocked　with　a　cancer　cell-specific　aptamer,　AS1411,　and　a　replaceable　anti-biomarker　probe　(ABP).　We　demonstrated　that　this　DNA　nanodrug　was　directed　to　cancer　cells　with　the　guidance　power　of　AS1411　and　then　activated　by　the　presence　of　a　given　intracellular　biomarker.　By　using　such　a　belt-and-braces　strategy,　this　DNA　nanodrug　system　could　safely　and　efficiently　accelerate　apoptosis　of　target　cancer　cells.　Moreover,　since　the　expression　level　of　biomarkers　tends　to　indicate　the　specific　physiological　state　of　individual　cells,　biomarker-responsive　activation　of　the　nanodrug　is　expected　to　enable　customized　drug　administration　at　the　cellular　level.　©　2018,　Science　China　Press　and　Springer-Verlag　GmbH　Germany,　part　of　Springer　Nature.

Keyword：

antisense oligonucleotides; aptamer; drug delivery; personalized medicine

Community：

  • [ 1 ] [Li, J.]Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, Aptamer Engineering Center of Hunan Province, Hunan University, Hunan, 410082, China
  • [ 2 ] [Qiu, L.]Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, Aptamer Engineering Center of Hunan Province, Hunan University, Hunan, 410082, China
  • [ 3 ] [Xie, S.]Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, Aptamer Engineering Center of Hunan Province, Hunan University, Hunan, 410082, China
  • [ 4 ] [Zhang, J.]Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, Aptamer Engineering Center of Hunan Province, Hunan University, Hunan, 410082, China
  • [ 5 ] [Zhang, L.]Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, Aptamer Engineering Center of Hunan Province, Hunan University, Hunan, 410082, China
  • [ 6 ] [Zhang, L.]Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200, United States
  • [ 7 ] [Liu, H.]Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, Aptamer Engineering Center of Hunan Province, Hunan University, Hunan, 410082, China
  • [ 8 ] [Li, J.]Key Laboratory for Analytical Science of Food Safety and Biology (Ministry of Education), College of Chemistry, Fuzhou University, Fuzhou, 350116, China
  • [ 9 ] [Zhang, X.]Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, Aptamer Engineering Center of Hunan Province, Hunan University, Hunan, 410082, China
  • [ 10 ] [Tan, W.]Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, Aptamer Engineering Center of Hunan Province, Hunan University, Hunan, 410082, China
  • [ 11 ] [Tan, W.]Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200, United States

Reprint 's Address：

  • [Qiu, L.]Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, Aptamer Engineering Center of Hunan Province, Hunan UniversityChina

Email：


qiuliping@hnu.edu.cn
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Source ：

Science China Chemistry

ISSN： 1674-7291

Year： 2018

Issue： 4

Volume： 61

Page： 497-504

6 . 0 8 5

JCR@2018

1 0 . 4 0 0

JCR@2023

ESI HC Threshold：209

JCR Journal Grade：1

CAS Journal Grade：3

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 16

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 0

Affiliated Colleges：

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