A study on the role that quorum sensing play in antibiotic-resistant plasmid conjugative transfer in Escherichia coli - Details

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Abstract：

Horizontal　genes　transfer　(HGT)　plays　an　important　role　in　the　dissemination　of　antibiotic　resistance　genes　(ARGs)　in　the　environment.　However,　the　mechanisms　of　HGT　of　ARGs　under　the　influence　of　antibiotics　in　sub-MIC　remain　rarely　explored.　Moreover,　given　its　collective　nature,　HGT　was　considered　to　be　relative　to　quorum　sensing　(QS)　system.　To　investigate　whether　QS　has　any　impact　on　horizontal　gene　transfer　of　ARGs,　experiments　were　conducted　to　determine　the　conjugative　efficiency　of　plasmid　RP4　on　Escherichia　coli　(E.coli)　under　the　influences　of　tetracyclines　(TCs),　quorum　sensing　autoinducers　(AIs)　and　quorum　sensing　inhibitors　(QSIs).　The　results　indicated　that　the　sub-MIC　TCs　could　facilitate　the　conjugative　transfer　of　RP4,　a　process　which　could　be　enhanced　by　AIs　but　inhibited　by　QSIs.　This　study　demonstrated　the　roles　that　QS　played　in　the　dissemination　of　ARGs,　and　provided　theoretical　insights　into　the　mechanism　of　HGT　of　ARGs　in　the　environment.　©　2018,　Springer　Science+Business　Media,　LLC,　part　of　Springer　Nature.

Keyword：

Antibiotic resistance genes; Conjugative transfer; Escherichia coli; Plasmid RP4; Quorum sensing

Community：

[ 1 ] [Zhang, Y.]State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai, 200092, China
[ 2 ] [Zhang, Y.]College of Marine Ecology and Environment, Shanghai Ocean University, Shanghai, 201306, China
[ 3 ] [Ma, Q.]State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai, 200092, China
[ 4 ] [Ma, Q.]College of Marine Ecology and Environment, Shanghai Ocean University, Shanghai, 201306, China
[ 5 ] [Su, B.]Fujian Provincial Key Laboratory of Marine Enzyme Engineering, Fuzhou University, Fuzhou, 350116, China
[ 6 ] [Chen, R.]State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai, 200092, China
[ 7 ] [Lin, J.]Fujian Provincial Key Laboratory of Marine Enzyme Engineering, Fuzhou University, Fuzhou, 350116, China
[ 8 ] [Lin, Z.]State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai, 200092, China
[ 9 ] [Lin, Z.]Shanghai Institute of Pollution Control and Ecological Security, Shanghai, 200092, China
[ 10 ] [Lin, Z.]Shanghai Key Lab of Chemical Assessment and Sustainability, Shanghai, 201306, China
[ 11 ] [Wang, D.]State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai, 200092, China
[ 12 ] [Yu, Y.]Solid Waste and Chemicals Management Center, Ministry of Environmental Protection, Beijing, 100029, China

Reprint 's Address：

[Lin, Z.]State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji UniversityChina

Email：

lzhifen@tongji.edu.cn

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Source ：

Ecotoxicology

ISSN： 0963-9292

Year： 2018

Issue： 2

Volume： 27

Page： 209-216

2 . 4 6

JCR@2018

2 . 5 0 0

JCR@2023

ESI HC Threshold：222

JCR Journal Grade：2

CAS Journal Grade：3

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 24

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 2

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