• Complex
  • Title
  • Keyword
  • Abstract
  • Scholars
  • Journal
  • ISSN
  • Conference
成果搜索

author:

Guo, Y. (Guo, Y..) [1] | Chen, Y. (Chen, Y..) [2] | Zhu, X. (Zhu, X..) [3] | Pan, Z. (Pan, Z..) [4] | Zhang, X. (Zhang, X..) [5] | Wang, J. (Wang, J..) [6] | Fu, N. (Fu, N..) [7]

Indexed by:

Scopus

Abstract:

“Aggregation-caused signal change”, a well-established mechanism, should not be ignored for sensing, while small molecule based on self-assembly and disaggregation has been studied and used for protein detection. In this work, we have synthesized a novel fluorescent chemosensor SQ with a polyether chain to enhance water solubility, and this has been used for the detection of human serum albumin (HSA) in aqueous solution with excellent sensitivity and selectivity. SQ was aggregated into nanoparticles with an average particle size of 458 nm in neutral solution and showed fluorescence silent due to the aggregation-induced quenching. However, addition of HSA decreased the average particle size of SQ to 295 nm and released the fluorescence because of the reassembly of the SQ-HSA complex. More importantly, HSA could be selectively detected in the presence of other biological proteins and the main physiological inorganic anions and cations with the detection limit estimated as 15.6 nM according to 3σ/k. This versatile strategy suggests that squaraine dyes can be used as fluorescence-enhanced probes for the quantitative detection of HSA as well as in applications for the detection of HSA in urine samples. © 2017 Elsevier B.V.

Keyword:

Disaggregation; Fluorescent probe; Human serum albumin; Nanosensor; Self-assembly; Squaraine

Community:

  • [ 1 ] [Guo, Y.]State Key Laboratory of Photocatalysis on Energy and Environment, Key Laboratory of Analysis and Detection for Food Safety, Ministry of Education & Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou, 350116, China
  • [ 2 ] [Chen, Y.]State Key Laboratory of Photocatalysis on Energy and Environment, Key Laboratory of Analysis and Detection for Food Safety, Ministry of Education & Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou, 350116, China
  • [ 3 ] [Zhu, X.]State Key Laboratory of Photocatalysis on Energy and Environment, Key Laboratory of Analysis and Detection for Food Safety, Ministry of Education & Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou, 350116, China
  • [ 4 ] [Pan, Z.]Agricultural Bio-Resources Research Institute, Fujian Academy of Agricultural Sciences, Fuzhou, 350003, China
  • [ 5 ] [Zhang, X.]Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Ministry of Education, Shenyang, 110016, China
  • [ 6 ] [Wang, J.]Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Ministry of Education, Shenyang, 110016, China
  • [ 7 ] [Fu, N.]State Key Laboratory of Photocatalysis on Energy and Environment, Key Laboratory of Analysis and Detection for Food Safety, Ministry of Education & Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou, 350116, China

Reprint 's Address:

  • [Fu, N.]State Key Laboratory of Photocatalysis on Energy and Environment, Key Laboratory of Analysis and Detection for Food Safety, Ministry of Education & Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou UniversityChina

Show more details

Related Keywords:

Related Article:

Source :

Sensors and Actuators, B: Chemical

ISSN: 0925-4005

Year: 2018

Volume: 255

Page: 977-985

6 . 3 9 3

JCR@2018

6 . 3 9 3

JCR@2018

JCR Journal Grade:1

CAS Journal Grade:1

Cited Count:

WoS CC Cited Count: 0

SCOPUS Cited Count: 33

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 5

Affiliated Colleges:

Online/Total:191/10021604
Address:FZU Library(No.2 Xuyuan Road, Fuzhou, Fujian, PRC Post Code:350116) Contact Us:0591-22865326
Copyright:FZU Library Technical Support:Beijing Aegean Software Co., Ltd. 闽ICP备05005463号-1