A black phosphorus nanosheet-based siRNA delivery system for synergistic photothermal and gene therapy - Details

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Abstract：

Gene　therapy　with　small　interfering　RNA　(siRNA)　has　been　proved　to　be　a　promising　technology　to　treat　various　diseases　by　hampering　the　production　of　target　proteins.　However,　developing　a　delivery　system　that　has　high　efficiency　in　transporting　siRNA　without　obvious　side　effects　remains　a　challenge.　Herein,　we　designed　a　new　survivin　siRNA　delivery　system　based　on　polyethyleneimine　functionalized　black　phosphorus　(BP)　nanosheets　which　could　suppress　tumor　growth　by　silencing　survivin　expression.　Combined　with　the　photothermal　properties　of　the　BP　nanosheets,　the　presented　delivery　system　shows　excellent　therapy　efficiency　for　tumors.　Therefore,　the　BP-based　delivery　system　would　be　a　promising　tool　for　future　clinical　applications.　©　2018　The　Royal　Society　of　Chemistry.

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[ 1 ] [Wang, H.]Key Laboratory for Analytical Science of Food Safety and Biology, MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 2 ] [Zhong, L.]Key Laboratory for Analytical Science of Food Safety and Biology, MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 3 ] [Liu, Y.]Key Laboratory for Analytical Science of Food Safety and Biology, MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 4 ] [Xu, X.]Key Laboratory for Analytical Science of Food Safety and Biology, MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 5 ] [Xing, C.]Key Laboratory for Analytical Science of Food Safety and Biology, MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 6 ] [Wang, M.]Key Laboratory for Analytical Science of Food Safety and Biology, MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 7 ] [Bai, S.-M.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, China
[ 8 ] [Lu, C.-H.]Key Laboratory for Analytical Science of Food Safety and Biology, MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 9 ] [Yang, H.-H.]Key Laboratory for Analytical Science of Food Safety and Biology, MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350116, China

Reprint 's Address：

[Lu, C.-H.]Key Laboratory for Analytical Science of Food Safety and Biology, MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou UniversityChina

Email：

chunhualu@fzu.edu.cn

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Source ：

Chemical Communications

ISSN： 1359-7345

Year： 2018

Issue： 25

Volume： 54

Page： 3142-3145

6 . 1 6 4

JCR@2018

4 . 3 0 0

JCR@2023

ESI HC Threshold：209

JCR Journal Grade：1

CAS Journal Grade：2

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 104

ESI Highly Cited Papers on the List： 0 Unfold All

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Chinese Cited Count：

30 Days PV： 0

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