Residue　curve　maps　are　a　powerful　tool　for　the　preliminary　design　of　Reactive　Distillation　(RD).　In　this　study,　residue　curve　maps　of　the　n-butyl　acetate　synthesis　reaction　were　calculated　based　on　the　Langmuir-Hinshelwood-Hougen-Watson　kinetic　and　UNIQUAC　models　to　calculate　the　physical　properties　of　the　system.　The　results　showed　that　the　unstable　node　branch　emerged　from　the　n-butyl　acetate/water　edge,　moved　toward　the　chemical　equilibrium　surface　with　increasing　Damköhler　number,　and　no　ternary　reactive　azeotropic　point　appeared　when　the　reaction　was　added.　Conceptual　design　of　n-butyl　acetate　synthesis　by　reactive　distillation　based　on　residue　curve　maps　is　presented.　Based　on　the　simulation　results,　both　the　energy　consumption　and　the　total　annual　cost　were　lower　than　previously　reported　values.　©　2018,　Iranian　Institute　of　Research　and　Development　in　Chemical　Industries.　All　rights　reserved.