Magnetic　hyperthermia　ablates　malignant　cells　by　the　heat　dissipating　from　magnetic　nanoparticles　(MNPs)　when　subjects　to　an　applied　magnetic　field.　The　treatment　effect　during　hyperthermia　is　significantly　related　to　many　factors,　but　is　primarily　decided　by　bio-tissue　intrinsic　characteristics　as　well　as　the　nanofluid　concentration　distribution　inside　tumor　region.　In　addition,　the　transient　bio-tissue　temperature　can　also　impact　the　treatment　effect　through　the　power　dissipation　of　MNPs　and　bio-heat　transfer　model　during　therapy.　This　paper　investigates　the　thermal　ablation　behavior　for　two　typical　malignant　cells　based　on　different　nanofluid　concentration　distribution,　in　which　the　transient　bio-tissue　temperature　is　considered　as　the　influence　factor　for　the　power　dissipation　of　MNPs　as　well　as　the　bio-heat　transfer　model　during　therapy.　The　simulation　results　demonstrate　that　a　Gaussian　distribution　with　lower　variance　for　nanofluid　concentration　should　have　a　worse　treatment　temperature　profile　than　the　case　with　a　higher　variance,　which　will　then　result　in　a　poor　ablation　situation　for　the　proposed　malignant　cells　during　therapy.　Meanwhile,　results　also　show　that　the　power　dissipation　of　MNPs　should　be　increased　properly　in　order　to　compensate　the　negative　effect　due　to　the　transient　bio-tissue　temperature　in　practical　application.　©　2020　Elsevier　B.V.