Login | Cas Login
English| 简体中文| 繁体中文

  • Complex
  • Title
  • Keyword
  • Abstract
  • Scholars
  • Journal
  • ISSN
  • Conference
成果搜索

Advanced Search

author：

Zhang, L. (Zhang, L..) [1] | Wang, J. (Wang, J..) [2] | Zhang, Y. (Zhang, Y..) [3] | Ke, L. (Ke, L..) [4] | Lin, X. (Lin, X..) [5] | Li, Z. (Li, Z..) [6] | Chen, H. (Chen, H..) [7] | Gao, Y. (Gao, Y..) [8]

Indexed by：

Scopus

Abstract：

The　outcome　of　application　of　epidermal　growth　factor　receptor　tyrosine　kinase　inhibitors　(EGFR-TKIs)in　patients　with　non-small-cell　lung　cancer　(NSCLC)always　suffers　from　acquired　drug　resistance.　Its　combination　with　other　therapies　has　been　explored　with　promising　synergistic　results.　Photodynamic　therapy　(PDT)is　an　established　treatment　modality　for　NSCLC,　but　the　low　tumor　selectivity　of　currently　available　photosensitizers　(PSs)hampered　the　wide　clinical　application　of　PDT.　Here,　we　synthesized　erlotinib　modified　chitosan　(ECs)by　click　coupling　and　developed　ECs/indocyanine　green　(ICG)self-assembled　nanoparticles　(GECs)for　combined　targeted　chemo-photodynamic　therapy.　GECs　showed　oval-shaped　particles　with　a　diameter　of　267.5　nm,　a　zeta　potential　of　−15.2　mV,　and　considerable　photostability.　In　vitro　release　experiment　showed　that　erlotinib　and　ICG　could　be　slowly　released　from　GECs　in　acidic　condition　with　lysozyme.　GECs　were　capable　of　generating　reactive　oxygen　species　(ROS)for　PDT　under　near-infrared　laser　irradiation.　GECs　showed　synergistic　molecular　targeted　and　photodynamic　therapeutic　effects　in　inhibition　of　cellular　growth　and　induction　of　apoptosis　in　NSCLC　cells.　This　study　demonstrated　that　the　GECs　could　be　a　promising　platform　by　combination　of　targeted　chemo-photodynamic　therapy　for　NSCLC　treatment.　©　2019　Elsevier　Ltd

Keyword：

Chitosan; Erlotinib; Indocyanine green; NSCLC; Photodynamic therapy

Community：

  • [ 1 ] [Zhang, L.]Cancer Metastasis Alert and Prevention Center, Biopharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 2 ] [Zhang, L.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350108, China
  • [ 3 ] [Wang, J.]Cancer Metastasis Alert and Prevention Center, Biopharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 4 ] [Wang, J.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350108, China
  • [ 5 ] [Zhang, Y.]Cancer Metastasis Alert and Prevention Center, Biopharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 6 ] [Zhang, Y.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350108, China
  • [ 7 ] [Ke, L.]Cancer Metastasis Alert and Prevention Center, Biopharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 8 ] [Ke, L.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350108, China
  • [ 9 ] [Lin, X.]Cancer Metastasis Alert and Prevention Center, Biopharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 10 ] [Lin, X.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350108, China
  • [ 11 ] [Li, Z.]Cancer Metastasis Alert and Prevention Center, Biopharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 12 ] [Li, Z.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350108, China
  • [ 13 ] [Chen, H.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350108, China
  • [ 14 ] [Gao, Y.]Cancer Metastasis Alert and Prevention Center, Biopharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 15 ] [Gao, Y.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350108, China

Reprint 's Address：

  • [Gao, Y.]Fuzhou University, 2 Xueyuan Road, Yangguang Building, 6FL., China

Email：


hellogaoyu@126.com
Show more details

Related Keywords：

Related Article：

Source ：

Dyes and Pigments

ISSN： 0143-7208

Year： 2019

Volume： 170

4 . 6 1 3

JCR@2019

4 . 1 0 0

JCR@2023

ESI HC Threshold：184

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 0

Affiliated Colleges：

Get Fulltext

DOI Library Discovery Baidu Scholar Search SCOPUS
Online/Total：472/10022870
Address：FZU Library(No.2 Xuyuan Road, Fuzhou, Fujian, PRC Post Code：350116) Contact Us：0591-22865326
Copyright：FZU Library Technical Support：Beijing Aegean Software Co., Ltd. 闽ICP备05005463号-1