Cube-like　anatase　TiO2　mesocrystals　have　been　fabricated　successfully　by　using　amorphous　titanate　as　a　precursor.　The　size　and　shape　of　the　synthesized　mesocrystals　are　uniform　with　an　average　size　of　100　nm.　Interestingly,　the　low　index　facets　of　(100),　(010)　and　(001)　are　exposed　completely,　forming　the　special　cube-like　shape.　When　used　as　an　anode　for　lithium-ion　batteries,　anatase　TiO2　mesocrystals　exhibit　an　excellent　lithium　storage　ability.　A　capacity　of　166　mA　h　g−1　can　be　remained　after　800　cycles　at　5C,　demonstrating　a　good　long-term　cycling　performance.　Furthermore,　an　average　reversible　capacity　of　148　mA　h　g−1　can　be　also　maintained　even　at　a　rate　as　high　as　20C.　Such　an　excellent　electrochemical　performance　can　be　attributed　to　the　special　cube-like　shape　of　TiO2　mesocrystals　with　exposed　facets,　which　facilitate　lithium-ion　diffusion.　©　2019　Elsevier　Ltd