To　achieve　the　clinical　application　of　photothermal　nanomaterials　in　tumor　treatment,　developing　photothermal　therapeutic　agents　with　a　strong　photothermal　therapeutic　effect,　good　photostability　and　rapid　clearance　or　dissociation　abilities　are　urgently　desired.　Herein,　epigallocatechin　gallate-iron　coordination　nanocomplexes　with　high　photothermal　conversion　capability,　magnetic　resonance　(MR)/photoacoustic　(PA)　imaging　ability　and　rapid　degradation　ability　under　high　GSH　condition　were　prepared.　(abbreviated　as　EGCG-Fe/PVP　NCs).　The　EGCG-Fe/PVP　NCs　were　composed　through　a　coordination　reaction　between　Fe3+　and　EGCG　upon　the　protection　of　polyvinyl　pyrrolidone　(PVP).　For　its　application　in　the　biomedical　field,　using　electronegativity　from　the　polyhydroxy　characteristics　of　EGCG,　these　complexes　were　controlled　to　cap　the　pores　of　the　DOX-loaded　and　aminated　mesoporous　silica　nanoparticles　via　electrostatic　attraction　to　form　a　multimodal　imaging-guided　combined　chemo　and　photothermal　therapy　nanoplatform　(abbreviated　as　MDEF　NPs).　The　prepared　MDEF　NPs　exhibit　high　drug　loading　efficiency　and　favorable　pH-dependent　drug　release　capacity.　In　vitro　cytotoxicity　data　showed　that　MDEF　NPs　in　the　laser　exposure　group　exhibited　stronger　cytotoxicity　than　other　groups.　Therefore,　this　work　may　expand　the　application　of　MSNs　and　EGCG-Fe/PVP　NCs　in　the　biological　field.　©　2019　Wiley-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim