Development　of　chiral　metal-organic　frameworks　(MOFs)　for　circularly　polarized　luminescence　(CPL)　is　a　challenging　but　important　task.　In　this　work,　we　report　a　first　example　of　azapyrene-based　chiral　MOF　thin　films　[Zn2Cam2DAP]n　grown　on　functionalized　substrates　(named　SURchirMOF-4)　for　CPL　property.　By　using　a　liquid-phase　epitaxial　layer-by-layer　method,　the　resulted　SURchirMOF-4　was　constructed　from　chiral　camphoric　acid　and　2,7-diazapyrene　ligand,　which　has　high　orientation　and　homogeneity.　The　circular　dichroism,　CPL,　and　enantioselective　adsorption　results　show　that　SURchirMOF-4　has　strong　chirality　and　CPL　property　as　well　as　good　enantioselective　adsorption　toward　enantiomers　of　methyl-lactate.　The　synthesis　of　azapyrene-based　chiral　MOF　thin　films　not　only　represents　an　ideal　model　for　studying　the　enantioselective　adsorption,　but　also　will　be　a　valuable　approach　for　development　of　the　chiral　thin　film　exhibiting　CPL　property.　Copyright　©　2019　American　Chemical　Society.