Cocatalysts　play　a　significant　role　in　accelerating　the　catalytic　reactions　of　semiconductor　photocatalyst.　In　particular,　a　semiconductor　assembled　with　dual　cocatalysts,　i.e.,　reduction　and　oxidation　cocatalysts,　can　obviously　enhance　the　photocatalytic　performance　because　of　the　synergistic　effect　of　fast　consumption　of　photogenerated　electrons　and　holes　simultaneously.　However,　in　most　cases,　noble　metal　cocatalysts　are　employed,　which　tremendously　increases　the　cost　of　the　photocatalysts　and　restricts　their　large-scale　applications.　Herein,　on　the　platform　of　one-dimensional　(1D)　CdS　nanowires,　we　have　utilized　the　earth-abundant　dual　cocatalysts,　MoS2　and　cobalt　phosphate　(Co-Pi),　to　construct　the　CdS@MoS2@Co-Pi　(CMC)　core-shell　hybrid　photocatalysts.　In　this　dual-cocatalyst　system,　Co-Pi　is　in　a　position　to　expedite　the　migration　of　holes　from　CdS,　while　MoS2　acts　as　an　electron　transporter　as　well　as　active　sites　to　accelerate　the　surface　water　reduction　reaction.　Taking　the　advantages　of　the　dual-cocatalyst　system,　the　prepared　CMC　hybrid　shows　an　obvious　enhancement　of　both　the　photoactivity　and　photostability　toward　hydrogen　production　compared　with　bare　1D　CdS　nanowires　and　binary　hybrids　(CdS@MoS2　and　CdS@Co-Pi).　This　work　highlights　the　promising　prospects　for　rational　utilization　of　earth-abundant　dual　cocatalysts　to　design　low-cost　and　efficient　hybrids　toward　boosting　photoredox　catalysis.　©　2019　American　Chemical　Society.