Bispecific Aptamer Induced Artificial Protein-Pairing: A Strategy for Selective Inhibition of Receptor Function - Details

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Abstract：

Cell　surface　receptors　play　a　critical　role　in　modulating　intracellular　signal　transduction,　making　them　important　drug　targets.　However,　it　remains　challenging　to　develop　a　selective　and　efficient　strategy　for　regulating　receptor　function.　Herein,　we　develop　a　strategy,　called　bispecific　aptamer　induced　artificial　protein-pairing,　to　selectively　regulate　receptor　function.　In　this　strategy,　bispecific　aptamer　probes　act　as　molecular　mediators　to　bind　to　both　a　target　receptor　protein　and　a　paired　protein,　which　brings　the　two　proteins　into　close　proximity　on　the　living　cell　membrane.　Importantly,　the　paired　proteins　work　not　only　as　a　cancer　biomarker　for　enhancing　cell　selectivity　but　also　as　a　blocking　assistant　to　inhibit　target　receptor　function　via　strong　steric　hindrance　effect.　Compared　with　single-aptamer-mediated　regulation,　the　proposed　bispecific　aptamer　probes　afford　substantial　improvement　in　selective　and　efficient　regulation　of　receptor　function　and　downstream　signaling　pathways.　This　work　offers　a　versatile　methodology　to　design　molecular　mediators　that　can　modulate　receptor　function,　thereby　providing　a　new　way　for　developing　novel　therapeutic　drugs.　©　2019　American　Chemical　Society.

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[ 1 ] [Wang, L.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 2 ] [Wang, L.]Institute of Molecular Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China
[ 3 ] [Liang, H.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 4 ] [Liang, H.]Institute of Oceanography, Minjiang University, Fuzhou, Fujian, 350108, China
[ 5 ] [Sun, J.]Institute of Molecular Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China
[ 6 ] [Sun, J.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350108, China
[ 7 ] [Liu, Y.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 8 ] [Li, J.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 9 ] [Li, J.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350108, China
[ 10 ] [Li, J.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 11 ] [Li, J.]Institute of Molecular Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China
[ 12 ] [Yang, H.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China

Reprint 's Address：

[Li, J.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou UniversityChina

Email：

lijuan@fzu.edu.cn

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Journal of the American Chemical Society

ISSN： 0002-7863

Year： 2019

Issue： 32

Volume： 141

Page： 12673-12681

1 4 . 6 1 2

JCR@2019

1 4 . 5 0 0

JCR@2023

ESI HC Threshold：184

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 108

ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 0

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