Functionalized Eu(III)-based nanoscale metal-organic framework for enhanced targeted anticancer therapy - Details

author：

Chen, P. (Chen, P..) ^[1] | Huang, Y.-F. (Huang, Y.-F..) ^[2] | Xu, G.-Y. (Xu, G.-Y..) ^[3] | Xue, J.-P. (Xue, J.-P..) ^[4] | Chen, J.-J. (Chen, J.-J..) ^[5]

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Abstract：

To　improve　the　cancer　targeting　and　anticancer　efficacy,　the　multifunctional　Eu-based　metal-organic　framework　(EuBTC)　is　post-synthetically　modified　with　a　targeting　moiety　folic　acid　and　a　zinc　phthalocyanine　photosensitizer.　In　addition,　this　nanosphere　is　also　applied　as　a　drug　delivery　system　to　load　the　chemical　drug　doxorubicin.　Electron　microscopy,　powder　X-ray　diffraction　and　infrared　spectometry　demonstrated　the　formation　of　these　multifunctional　nanospheres　(DOX).　Our　nanospheres　kept　the　high　singlet　oxygen　quantum　yield　of　zinc　phthalocyanine.　Additionally,　Cell　viability　experiments　demonstrated　the　biosafety　of　EuBTC　and　the　enhanced　anticancer　effect　of　DOX@FA-EuBTC-Pc　under　light　irradiation.　In　short,　these　well-arranged　DOX@FA-Eu-BTC-Pcs　exhibit　as　promising　drug　delivery　systems　for　enhanced　targeted　anticancer　therapy.　©　2019　World　Scientific　Publishing　Company.

Keyword：

cancer targeting; combination therapy; metal-organic framework; photodynamic therapy; post-synthetic modification

Community：

[ 1 ] [Chen, P.]National and Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, And Fujian Engineering Research Center for Drug and Diagnoses and Treatment of Photodynamic Therapy, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China
[ 2 ] [Huang, Y.-F.]National and Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, And Fujian Engineering Research Center for Drug and Diagnoses and Treatment of Photodynamic Therapy, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China
[ 3 ] [Xu, G.-Y.]National and Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, And Fujian Engineering Research Center for Drug and Diagnoses and Treatment of Photodynamic Therapy, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China
[ 4 ] [Xue, J.-P.]National and Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, And Fujian Engineering Research Center for Drug and Diagnoses and Treatment of Photodynamic Therapy, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China
[ 5 ] [Chen, J.-J.]National and Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, And Fujian Engineering Research Center for Drug and Diagnoses and Treatment of Photodynamic Therapy, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China

Reprint 's Address：

[Chen, J.-J.]National and Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, And Fujian Engineering Research Center for Drug and Diagnoses and Treatment of Photodynamic Therapy, College of Chemistry, Fuzhou UniversityChina

Email：

cjj_pp@126.com

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Source ：

Journal of Porphyrins and Phthalocyanines

ISSN： 1088-4246

Year： 2019

Issue： 6

Volume： 23

Page： 619-627

1 . 8 1 6

JCR@2019

0 . 9 0 0

JCR@2023

ESI HC Threshold：184

JCR Journal Grade：3

CAS Journal Grade：4

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 1

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