Polybrominated　diphenyl　ethers　(PBDEs)　are　widely　used　as　flame　retardants　and　challenges　for　water　treatment　due　to　their　persistence　and　toxicity.　In　this　study,　the　reduction　of　2′2′4′4′-tetrabromodiphenyl　ether　(BDE-47)　was　investigated　in　a　nano-bio-integrated　system.　Results　showed　that　the　introducing　of　P.　putida　could　markedly　accelerate　the　demineralization　of　BDE-47　in　nZVI/Pd-P.p　system;　the　continuous　generation　of　acidic　metaboliates　by　P.　putida　could　decrease　pH,　which　could　alleviate　the　surface　passivation　to　some　extent,　resulting　in　the　releasing　of　Fe2+　and　high　generation　of　H2O2,　the　shift　in　reactive　oxygen　species　from　Fe(IV)　to　•OH.　The　BDE-47　was　firstly　debrominated　to　the　DE　by　the　highly　reductive　[Pd·2H]　generated　by　nZVI/Pd,　then　oxidized　to　bromophenol　and　phenol,　catechol　as　well　as　hydroquinone　via　the　P.　putida　strain　and　the　Fenton-like　system.　The　toxicity　assays　confirmed　the　combined　system　could　avert　generation　of　nocuous　intermediates,　and　could　be　an　alternative　strategy　for　complete　remediation　of　recalcitrant　POPs.　©　2019　Elsevier　Ltd