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author：

Zhang, Y. (Zhang, Y..) [1] | Wang, R. (Wang, R..) [2] | Zhang, T. (Zhang, T..) [3] | Yan, W. (Yan, W..) [4] | Chen, Y. (Chen, Y..) [5] | Zhou, M. (Zhou, M..) [7]

Indexed by：

Scopus CSCD

Abstract：

A　series　of　novel　benzofuran-isatin-hydroxylimine/thiosemicarbazide　hybrids　were　designed,　synthesized　and　evaluated　for　their　in　vitro　anti-TB　activities　against　drug-sensitive　MTB　H　37　Rv　and　MDR-TB　isolates　as　well　as　cytotoxicity.　All　benzofuran-isatin-hydroxylimine/thiosemicarbazide　hybrids　exhibited　considerable　in　vitro　anti-mycobacterial　activities　against　the　tested　three　MTB　strains,　and　all　of　them　also　showed　acceptable　cytotoxicity.　The　most　active　hybrid　7f　was　>4.8　and　>51　folds　more　potent　than　the　first　line　anti-TB　agents　RIF　and　INH　against　both　drug-sensitive　MTB　H　37　Rv　and　MDR-TB　isolates,　respectively.　The　results　demonstrated　the　potential　utility　of　benzofuran-isatin-hydroxylimine/-thiosemicarbazide　hybrids　as　anti-TB　agents.　©　2019　The　Author

Keyword：

Anti-mycobacterial; Anti-tubercular; Benzofuran; Hybrid compounds; Isatin; Multi-drug resistant; Structure-activity relationship

Community：

  • [ 1 ] [Zhang, Y.]College of Chemistry, Fuzhou University, Fuzhou, 350116, China
  • [ 2 ] [Wang, R.]College of Chemistry, Fuzhou University, Fuzhou, 350116, China
  • [ 3 ] [Zhang, T.]College of Chemistry, Fuzhou University, Fuzhou, 350116, China
  • [ 4 ] [Yan, W.]College of Chemistry, Fuzhou University, Fuzhou, 350116, China
  • [ 5 ] [Chen, Y.]College of Chemistry, Fuzhou University, Fuzhou, 350116, China
  • [ 6 ] [Zhang, Y.]College of Chemistry, Fuzhou University, Fuzhou, 350116, China
  • [ 7 ] [Zhou, M.]College of Chemistry, Fuzhou University, Fuzhou, 350116, China

Reprint 's Address：

  • [Wang, R.]College of Chemistry, Fuzhou UniversityChina

Email：


wangruo1201@gmail.com
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Source ：

Chinese Chemical Letters

ISSN： 1001-8417

Year： 2019

Issue： 3

Volume： 30

Page： 653-655

4 . 6 3 2

JCR@2019

9 . 4 0 0

JCR@2023

ESI HC Threshold：184

JCR Journal Grade：2

CAS Journal Grade：2

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 2

Affiliated Colleges：

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