Self-Assembled Metal-Phenolic Nanoparticles for Enhanced Synergistic Combination Therapy against Colon Cancer - Details

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Abstract：

Engineering　functional　nanomaterials　to　have　both　high　therapeutic　efficacy　and　minimal　side-effects　has　become　a　promising　strategy　for　next-generation　cancer　treatments.　Herein,　an　adenosine　triphosphate　(ATP)　depletion　and　reactive　oxygen　species-enhanced　combination　chemotherapy　platform　is　introduced　whereby　therapeutic　samarium　(Sm3+)　ions　and　(−)-epicatechin　(EC)　are　integrated　via　a　metal-phenolic　network　(SmIII-EC).　The　independent　pathway　between　Sm3+　and　EC　can　achieve　a　synergistic　therapeutic　effect　through　the　mitochondrial　dysfunction　process.　SmIII-EC　nanoparticles　cause　a　significant　reduction　of　viability　of　C26　murine　colon　carcinoma　cells　while　with　lower　systemic　toxic　effects　on　normal　cell　lines.　SmIII-EC　nanoparticles　are　used　to　directly　compare　with　a　clinic　anticancer　drug　5-fluorouracil.　SmIII-EC　nanoparticles　not　only　decrease　the　tumor　volume　but　also　do　not　affect　the　body　weight　of　mice　and　normal　organs,　showing　significant　advantages　over　clinic　counterpart.　These　facts　suggest　that　SmIII-EC　nanoparticles　represent　a　clinically　promising　candidate　for　colon　cancer　treatment　with　a　targeted　therapeutic　effect　and　minimum　side　toxicity.　©　2018　WILEY-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim

Keyword：

colon cancer; combination therapy; metal-phenolic networks; rare earth; ROS

Community：

[ 1 ] [Li, K.]Department of Biomass Science and Engineering, Sichuan University, Chengdu, 610065, China
[ 2 ] [Dai, Y.]Faculty of Health Sciences, University of Macau999078, Macau
[ 3 ] [Chen, W.]Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, United States
[ 4 ] [Yu, K.]Department of Biomass Science and Engineering, Sichuan University, Chengdu, 610065, China
[ 5 ] [Xiao, G.]Department of Environmental Science and Engineering, College of Environment and Resources, Fuzhou University, Fuzhou, 350108, China
[ 6 ] [Xiao, G.]Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA 02115, United States
[ 7 ] [Richardson, J.J.]ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and Department of Chemical Engineering, The University of Melbourne, Parkville, VIC 3010, Australia
[ 8 ] [Huang, W.]Laboratory of Ethnopharmacology, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
[ 9 ] [Guo, J.]Department of Biomass Science and Engineering, Sichuan University, Chengdu, 610065, China
[ 10 ] [Guo, J.]Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA 02115, United States
[ 11 ] [Liao, X.]Department of Biomass Science and Engineering, Sichuan University, Chengdu, 610065, China
[ 12 ] [Shi, B.]Department of Biomass Science and Engineering, Sichuan University, Chengdu, 610065, China

Reprint 's Address：

[Guo, J.]Department of Biomass Science and Engineering, Sichuan UniversityChina

Email：

junling.guo@wyss.harvard.edu

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Source ：

Advanced Biosystems

ISSN： 2366-7478

Year： 2019

Issue： 2

Volume： 3

4 . 1 0 0

JCR@2022

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WoS CC Cited Count：

SCOPUS Cited Count： 41

ESI Highly Cited Papers on the List： 0 Unfold All

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Chinese Cited Count：

30 Days PV： 0

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