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author：

Deng, J. (Deng, J..) [1] | Guo, W. (Guo, W..) [2] | Guo, J. (Guo, J..) [3] | Li, Y. (Li, Y..) [4] | Zhou, W. (Zhou, W..) [5] | Lv, W. (Lv, W..) [6] | Li, L. (Li, L..) [7] | Liu, B. (Liu, B..) [8] | Xia, G. (Xia, G..) [9] | Ni, L. (Ni, L..) [10] | Rao, P. (Rao, P..) [11] | Lv, X. (Lv, X..) [12]

Indexed by：

Scopus

Abstract：

The　aim　of　present　study　was　to　investigate　the　regulatory　effects　of　an　extract　of　the　Grifola　frondosa　on　glycolipid　metabolism　and　the　intestinal　flora　in　high-fat　diet　fed　rats.　The　ethyl　acetate　extract　of　G.　frondosa　(EAE),　enriched　with　pseudobaptigenin　and　cyanidin　3-O-xylosylrutinoside,　exerted　a　stronger　inhibitory　effect　on　lipase　than　the　other　polar　fractions　of　G.　frondosa　in　vitro.　Supplementation　with　EAE　(50　mg/kg)　to　rats　for　8　weeks　clearly　ameliorated　dyslipidaemia　by　suppressing　the　serum　levels　of　glucose　(Glu),　total　triglycerides　(TG)　and　low-density　lipoprotein　cholesterol　(LDL-C),　and　hepatic　fat　accumulation.　Furthermore,　EAE　supplementation　normalized　the　intestinal　flora　structure　in　high-fat　diet　fed　rats.　The　relevance　analysis　suggested　strong　associations　of　Anaerotruncus,　Barnesiella,　Clostridiaceae,　Erysipelotrichaceae,　Paraprevotella,　Clostridium_XVIII,　Coprococcus　and　Turicibacter　with　the　biochemical　indexes.　Simultaneously,　the　EAE　treatment　intervened　the　expression　levels　of　the　genes　associated　with　glycolipid　metabolism.　Our　results　indicated　that　pseudobaptigenin　and　cyanidin-3-O-xylosylrutinoside　can　be　used　as　pharmaceutical　agents　for　the　prevention　of　the　disorder　of　glycolipid　metabolism.　©　2020　The　Authors

Keyword：

Cyanidin-3-O-xylosylrutinoside; Glycolipid metabolism; Grifola frondosa; Gut microbiota; mRNA expression; Pseudobaptigenin

Community：

  • [ 1 ] [Deng, J.]School of Ocean Science and Biochemistry Engineering, Fuqing Branch of Fujian Normal University, Fuqing, Fujian 350300, China
  • [ 2 ] [Guo, W.]Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian 350108, China
  • [ 3 ] [Guo, W.]College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China
  • [ 4 ] [Guo, J.]Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, Fujian 350001, China
  • [ 5 ] [Li, Y.]College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China
  • [ 6 ] [Zhou, W.]Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian 350108, China
  • [ 7 ] [Zhou, W.]College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China
  • [ 8 ] [Lv, W.]Department of Radiation Oncology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China
  • [ 9 ] [Li, L.]Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian 350108, China
  • [ 10 ] [Li, L.]College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China
  • [ 11 ] [Liu, B.]College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China
  • [ 12 ] [Xia, G.]Department of Paediatrics, The 900th Hospital of Joint Logistic Support Force, PLA, Fuzhou, Fujian 350025, China
  • [ 13 ] [Ni, L.]Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian 350108, China
  • [ 14 ] [Rao, P.]Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian 350108, China
  • [ 15 ] [Lv, X.]School of Ocean Science and Biochemistry Engineering, Fuqing Branch of Fujian Normal University, Fuqing, Fujian 350300, China
  • [ 16 ] [Lv, X.]Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian 350108, China
  • [ 17 ] [Lv, X.]College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China

Reprint 's Address：

  • [Xia, G.]Institute of Food Science and Technology, College of Biological Science and Engineering, Fuzhou UniversityChina

Email：


gzx0691@163.com
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Source ：

Journal of Functional Foods

ISSN： 1756-4646

Year： 2020

Volume： 75

4 . 4 5 1

JCR@2020

3 . 8 0 0

JCR@2023

ESI HC Threshold：116

JCR Journal Grade：1

CAS Journal Grade：2

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 9

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 0

Affiliated Colleges：

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