Early stratification of radiotherapy response by activatable inflammation magnetic resonance imaging - Details

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Tumor　heterogeneity　is　one　major　reason　for　unpredictable　therapeutic　outcomes,　while　stratifying　therapeutic　responses　at　an　early　time　may　greatly　benefit　the　better　control　of　cancer.　Here,　we　developed　a　hybrid　nanovesicle　to　stratify　radiotherapy　response　by　activatable　inflammation　magnetic　resonance　imaging　(aiMRI)　approach.　The　high　Pearson’s　correlation　coefficient　R　values　are　obtained　from　the　correlations　between　the　T1　relaxation　time　changes　at　24–48　h　and　the　ensuing　adaptive　immunity　(R　=　0.9831)　at　day　5　and　the　tumor　inhibition　ratios　(R　=　0.9308)　at　day　18　after　different　treatments,　respectively.　These　results　underscore　the　role　of　acute　inflammatory　oxidative　response　in　bridging　the　innate　and　adaptive　immunity　in　tumor　radiotherapy.　Furthermore,　the　aiMRI　approach　provides　a　non-invasive　imaging　strategy　for　early　prediction　of　the　therapeutic　outcomes　in　cancer　radiotherapy,　which　may　contribute　to　the　future　of　precision　medicine　in　terms　of　prognostic　stratification　and　therapeutic　planning.　©　2020,　This　is　a　U.S.　government　work　and　not　under　copyright　protection　in　the　U.S.;　foreign　copyright　protection　may　apply.

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[ 1 ] [Zhou, Z.]Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, United States
[ 2 ] [Deng, H.]Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, United States
[ 3 ] [Deng, H.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
[ 4 ] [Yang, W.]Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, United States
[ 5 ] [Wang, Z.]Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, United States
[ 6 ] [Lin, L.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
[ 7 ] [Munasinghe, J.]Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, United States
[ 8 ] [Jacobson, O.]Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, United States
[ 9 ] [Liu, Y.]Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, United States
[ 10 ] [Tang, L.]Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, United States
[ 11 ] [Ni, Q.]Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, United States
[ 12 ] [Kang, F.]Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, United States
[ 13 ] [Liu, Y.]Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, United States
[ 14 ] [Niu, G.]Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, United States
[ 15 ] [Bai, R.]Interdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang University, Hangzhou, 310029, China
[ 16 ] [Qian, C.]Department of Radiology, Michigan State University, East Lansing, MI 48824, United States
[ 17 ] [Song, J.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
[ 18 ] [Chen, X.]Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, United States

Reprint 's Address：

[Chen, X.]Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou UniversityUnited States

Email：

shawn.chen@nih.gov

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Nature Communications

ISSN： 2041-1723

Year： 2020

Issue： 1

Volume： 11

1 4 . 9 1 9

JCR@2020

1 4 . 7 0 0

JCR@2023

ESI HC Threshold：420

JCR Journal Grade：1

CAS Journal Grade：1

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WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

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Chinese Cited Count：

30 Days PV： 0

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