Electrical　Impedance　Myography　(EIM)　based　on　the　four-electrode　method　is　a　novel　method　for　assessing　muscle　state　in　the　fields　of　sports,　fitness,　and　medical　rehabilitation.　However,　commonly　used　configuration　of　electrodes　is　not　suitable　for　the　wearable　field,　because　of　its　large　total　area　and　low　sensitivity.　An　optimized　electrode　configuration　for　wearable　application　is　proposed　as　Mode　B.　Equivalent　circuit　model　B　of　the　four-electrode　method　is　established　by　using　the　equivalent　circuit　of　biological　tissues,　and　in-vivo　measurements　of　the　electrical　impedance　of　the　biceps　muscle　are　carried　out　on　six　volunteers　using　bioimpedance　spectroscopy　device　ImpTM　SFB7.　The　experimental　results　show　that　equivalent　circuit　model　B　of　the　four-electrode　method　is　reliable.　Moreover,　the　variation　in　muscle　electrical　impedance　measured　using　the　optimal　configuration　of　model　B　is　twice　that　measured　using　the　optimal　configuration　of　model　A.　The　optimized　electrode　configuration　of　EIM　based　on　this　approach　is　model　B　(i.e.　square　electrodes　in　parallel　array;　size,　20　mm　×　20　mm;　spacing,　5–24　mm).　©　2020,　©　2020　The　Author(s).　Published　by　Informa　UK　Limited,　trading　as　Taylor　&　Francis　Group.