A Sandwich Nanostructure of Gold Nanoparticle Coated Reduced Graphene Oxide for Photoacoustic Imaging-Guided Photothermal Therapy in the Second NIR Window - Details

author：

Wang, Z. (Wang, Z..) ^[1] | Sun, X. (Sun, X..) ^[2] | Huang, T. (Huang, T..) ^[3] | Song, J. (Song, J..) ^[4] | Wang, Y. (Wang, Y..) ^[5]

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Abstract：

We　explore　a　sandwich-type　gold　nanoparticle　coated　reduced　graphene　oxide　(rGO-AuNP)　as　an　effective　nanotheranostic　platform　for　the　second　near-infrared　(NIR-II)　window　photoacoustic　(PA)　imaging-guided　photothermal　therapy　(PTT)　in　ovarian　cancer.　The　PEG　was　loaded　onto　the　AuNPs　surface　to　increase　the　stability　of　nanostructure.　The　forming　rGO-AuNPs-　PEG　revealed　very　strong　SERS　signal,　NIR-II　PA　signal　and　high　photothermal　efficiency　against　tumor　upon　1,061　nm　laser　irradiation.　The　prominent　performance　was　attributed　to　the　plasmonic　coupling　of　AuNPs,　and　the　enhanced　response　of　rGO　and　the　plasmonic　AuNP.　Thus,　our　study　demonstrates　that　the　rGO-AuNP　nanocomposite　could　promise　to　be　a　potential　photothermal　agent　and　pave　the　way　for　the　diagnosis　and　therapy　of　ovarian　cancer　in　the　future.　©　Copyright　©　2020　Wang,　Sun,　Huang,　Song　and　Wang.

Keyword：

gold nanoparticle; ovarian cancer; photoacoustic imaging; photothermal therapy; reduced graphene oxide; the second near-infrared window

Community：

[ 1 ] [Wang, Z.]Department of Gynecology, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
[ 2 ] [Wang, Z.]Shanghai Municipal Key Clinical Specialty, Shanghai, China
[ 3 ] [Wang, Z.]Shanghai Key Laboratory of Embryo Original Disease, Shanghai, China
[ 4 ] [Sun, X.]Department of Gynecology, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
[ 5 ] [Sun, X.]Shanghai Municipal Key Clinical Specialty, Shanghai, China
[ 6 ] [Sun, X.]Shanghai Key Laboratory of Embryo Original Disease, Shanghai, China
[ 7 ] [Huang, T.]Department of Gynecology, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
[ 8 ] [Huang, T.]Shanghai Municipal Key Clinical Specialty, Shanghai, China
[ 9 ] [Huang, T.]Shanghai Key Laboratory of Embryo Original Disease, Shanghai, China
[ 10 ] [Song, J.]MOE Key Laboratory for Analytical, Science of Food Safety and Biology College of Chemistry, Fuzhou University, Fuzhou, China
[ 11 ] [Wang, Y.]Department of Gynecology, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
[ 12 ] [Wang, Y.]Shanghai Municipal Key Clinical Specialty, Shanghai, China
[ 13 ] [Wang, Y.]Shanghai Key Laboratory of Embryo Original Disease, Shanghai, China

Reprint 's Address：

[Wang, Y.]Department of Gynecology, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Municipal Key Clinical Specialty, Shanghai Key Laboratory of Embryo Original Disease, MOE Key Laboratory for Analytical, Science of Food Safety and Biology College of Chemistry, Fuzhou UniversityChina

Email：

owangyudong@126.com

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Source ：

Frontiers in Bioengineering and Biotechnology

ISSN： 2296-4185

Year： 2020

Volume： 8

5 . 8 9

JCR@2020

4 . 3 0 0

JCR@2023

ESI HC Threshold：420

JCR Journal Grade：1

CAS Journal Grade：3

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WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

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Chinese Cited Count：

30 Days PV： 0

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