This　paper　aimed　to　design　a　miniaturised　electrochemical　analyser　(MEA)　for　glucose　determination　based　on　the　integration　of　chitosan　(CS),　glucose　oxidase　(GOD)　and　electroreduced　graphene　oxide　(e-RGO).　The　low-power　programmable　analog　front-end　LMP91000　and　the　microcontroller　STM32F103C8T6　were　combined　into　the　hardware　system　of　the　MEA.　The　potentiostat　function　of　the　system　was　realised　by　applying　the　setting　potential　on　the　three-electrode　sensor.　By　setting　the　trans-impedance　gain,　the　current　can　be　converted　from　a　full　range　of　5　uA　to　750　uA.　The　voltage　signal　was　converted　into　the　current　signal　using　an　algorithm　to　process　the　experimental　results.　Reliability　of　the　MEA　was　verified　by　electrochemical　workstation,　and　the　performance　was　tested　using　a　[Fe(CN6)]3-　solution.　The　MEA　showed　a　good　linear　relationship　between　the　final　steady-state　current　and　the　[Fe(CN6)]3-　concentration　in　the　dynamic　range　of　0.2　mM　to　10　mM　(R2=　0.9841).　GOD　was　fixed　on　a　working　electrode　(WE)　modified　with　e-RGO　to　prepare　the　glucose　sensor.　Finally,　different　glucose　concentrations　were　measured　using　chronoamperometry　with　the　MEA.　The　MEA　sensitivity　reached　169.32　mA/Mcm-2,　and　the　limit　of　detection　amounted　to　0.19　mM　according　to　35/slope　calculation.　©　2020　The　Authors.