Recent progress in developing of thrombolytic agents for ischemic stroke [缺血性脑卒中溶栓药物研究进展] - Details

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Abstract：

Ischemic　stroke　is　a　major　health　crisis　causing　high　mortality　and　morbidity.　The　key　treatment　relies　on　the　rapid　intervention　to　dissolve　thrombus,　to　reduce　bleeding　side　effect　and　re-canalize　clotted　blood　vessels　using　clot　lysis　drugs.　Tissue　plasminogen　activator　(tPA)　is　the　only　FDA-approved　drug　for　ischemic　stroke,　but　it　has　many　limitations　in　clinical　use.　In　recent　years,　the　development　of　thrombolytic　drugs　and　treatment　strategies　based　on　tPA　has　been　progressed　rapidly.　Here　we　review　the　recent　progress　in　this　field,　including　the　contributions　from　us　and　others,　to　promote　the　future　development　of　novel　thrombolytic　drugs.　©　2020,　Science　Press.　All　right　reserved.

Keyword：

Ischemic stroke; Thrombolysis; Tissue plasminogen activator

Community：

[ 1 ] [Xu, Y.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, China
[ 2 ] [Chen, S.]College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 3 ] [Chen, D.]College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 4 ] [Peng, S.]College of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China
[ 5 ] [Cheng, Y.]College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 6 ] [Li, J.]College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 7 ] [Li, Y.]Department of Neurology, Fujian Provincial Hospital, Provincial Clinical Department of Fujian Medical University, Fuzhou, 350001, China
[ 8 ] [Jiang, L.]College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 9 ] [Yuan, C.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, China
[ 10 ] [Huang, M.]College of Chemistry, Fuzhou University, Fuzhou, 350116, China

Reprint 's Address：

袁彩
[Yuan, C.]College of Biological Science and Engineering, Fuzhou University, College of Chemistry, Fuzhou UniversityChina

Email：

cyuan@fzu.edu.cn

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Source ：

Chinese Journal of Biotechnology

ISSN： 1000-3061

CN： 11-1998/Q

Year： 2020

Issue： 10

Volume： 36

Page： 2029-2039

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SCOPUS Cited Count： 1

ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 0

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