This　paper　proposes　an　advanced　approach　to　control　a　cascaded　H-bridge　multilevel　photovoltaic　(PV)　inverter　with　failed　cells　for　large-scale　grid-connected　applications.　A　major　challenge　of　these　PV　systems　come　from　the　uneven　power　distribution　among　the　PV　cells　on　the　same　phase　due　to　environmental　conditions,　which　then　leads　to　a　power　imbalance　between　the　three-phases.　The　power　imbalance　issue　can　also　come　from　the　presence　of　at　least　one　H-bridge　cell　fully　damaged　and　bypassed.　To　produce　a　balanced　three-phase　voltage　and　current　regardless　of　the　fact　that　the　phase-to-neutral　voltages　are　imbalanced,　a　neutral-shift　method　is　proposed　in　this　paper.　It　is　based　on　the　modification　of　the　PWM　reference　phase　voltage　angles　combined　to　injection　of　a　dynamic　homopolar　component.　A　multi-carrier　phase-disposition　PWM　strategy　with　a　switching　optimization　function　has　been　also　suggested.　©　2019　IEEE.