Noble　metal　nanoparticle-based　colorimetric　sensors　have　become　powerful　tools　for　the　detection　of　different　targets　with　convenient　readout.　Among　the　many　types　of　nanomaterials,　noble　metal　nanoparticles　exhibit　extraordinary　optical　responses　mainly　due　to　their　excellent　localized　surface　plasmon　resonance　(LSPR)　properties.　The　absorption　spectrum　of　the　noble　metal　nanoparticles　was　mostly　in　the　visible　range.　This　property　enables　the　visual　detection　of　various　analytes　with　the　naked　eye.　Among　numerous　color　change　modes,　the　way　that　different　concentrations　of　targets　represent　vivid　color　changes　has　been　brought　to　the　forefront　because　the　color　distinction　capability　of　normal　human　eyes　is　usually　better　than　the　intensity　change　capability.　We　review　the　state　of　the　art　in　noble　metal　nanoparticle-based　multicolor　colorimetric　strategies　adopted　for　visual　quantification　by　the　naked　eye.　These　multicolor　strategies　based　on　different　means　of　morphology　transformation　are　classified　into　two　categories,　namely,　the　etching　of　nanoparticles　and　the　growth　of　nanoparticles.　We　highlight　recent　progress　on　the　different　means　by　which　biocatalytic　reactions　mediated　LSPR　modulation　signal　generation　and　their　applications　in　the　construction　of　multicolor　immunoassays.　We　also　discuss　the　current　challenges　associated　with　multicolor　colorimetric　sensors　during　actual　sample　detection　and　propose　the　future　development　of　next-generation　multicolor　qualification　strategies.　©　2019　American　Chemical　Society.