Searching　biocompatible　electrochemiluminescence　(ECL)　co-reactants　for　tris(2,2’-bipyridyl)ruthenium(II)　(Ru(bpy)3　2+),　a　classical　ECL　reagent,　has　attracted　extensive　attention　to　expanding　its　analytical　applications　and　improving　sensing　performances.　Advances　in　nanomaterial　science　promote　the　discovery　of　novel　co-reactants　and　new　enhancement　mechanisms　for　Ru(bpy)3　2+　ECL.　In　this　Minireview,　we　discuss　the　current　progress　in　Ru(bpy)3　2+-nanomaterial　co-reactant　ECL　with　an　emphasis　on　enhancement　mechanisms　and　sensing　strategies　developed.　Four　kinds　of　nanomaterials　for　Ru(bpy)3　2+　ECL　enhancement　are　classified　into　two　groups,　according　to　the　working　mechanisms　and　presented　in　the　order　of　novelty.　Perspectives　on　the　promises　and　challenges　facing　this　field　are　also　discussed.　©　2019　Wiley-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim