In　order　to　analyze　the　influence　of　ultra-high　performance　concrete　layer　on　the　fatigue　performance　of　steel　bridge　deck,taking　the　steel　box　girder　of　Hong　Kong-Zhuhai-Macao　Bridge　as　an　example,a　layer　of　ultra-high　performance　concrete　was　added　to　the　panel　to　form　a　steel-UHPC　composite　deck.A　partial　steel　box　girder　section　model　with　UHPC　pavement　and　without　pavement　layer　was　established　by　using　finite　element　software　ABAQUS.For　the　orthotropic　steel　bridge　deck　with　UHPC　pavement,the　most　disadvantageous　detail　transverse　position　and　corresponding　most　disadvantageous　transverse　loading　point　at　the　longitudinal　rib-to-cover　connection　have　not　changed;　the　most　disadvantageous　detail　transverse　position　of　the　longitudinal　rib　at　the　longitudinal　rib-to-cover　connection,the　longitudinal　rib　web　and　diaphragm　web　at　the　longitudinal　rib-to-diaphragm　connection　have　not　changed,but　the　corresponding　most　disadvantageous　transverse　loading　point　has　changed;　the　most　disadvantageous　detail　transverse　position　at　the　butt　weld　of　the　diaphragm　web　incision　free　edge　and　the　longitudinal　rib　lower　edge　have　changed,the　corresponding　most　disadvantageous　transverse　loading　position　has　also　changed.UHPC　layer　greatly　increases　the　stiffness　of　steel　bridge　deck,which　greatly　reduces　the　stress　amplitude　level　of　each　fatigue　detail　and　the　probability　of　fatigue　cracking　of　each　detail.　©　2019,　Editorial　Department　of　Journal　of　SJZU.　All　right　reserved.