In　the　present　study　we　found　out　about　the　optimum　millisecond　time　for　reducing　vibration　in　hole-by-hole　blasting,　on　the　basis　of　an　actual　slope　detonation　work.　At　first　we　constructed　a　two-dimensional　static　model　using　ANSYS　and　determined　the　potential　sliding　surface　and　the　static　safety　factor　in　the　natural　state　using　finite　element　reduction.　Then　we　rebuilt　the　three-dimensional　dynamic　model　of　millisecond　hole-by-hole　blasting　and　carried　out　the　dynamic　analysis　using　LS-DYAN.　In　the　whole　process,　we　set　up　three　holes　in　the　same　row　using　millisecond　detonating　by　five　differential　millisecond　time　control　of　0,　17,　25,　42　and　65　ms.　At　the　end　of　the　construction　site,　we　conducted　small-scale　vibration　tests　of　four　millisecond　time　control　in　row　holes　(25　ms,　17　ms),　(25　ms,　25　ms),　(25　ms,　42　ms),　(25　ms,　65　ms),　with　the　stress　value　of　the　sliding　surface　unit　during　the　simultaneous　detonation　of　three　holes　in　the　simulated　results　taken　into　the　formula　of　limit　equilibrium,　and　drew　out　the　time　history　curve　of　slope　stability　coefficient　under　impact　loading.　Analyzing　the　time　history　curve,　we　found　that　the　optimum　millisecond　time　for　vibration　reduction　was　48　ms.　Moreover,　the　results　of　three-dimensional　numerical　simulation　and　vibration　test　showed　that　the　effect　of　vibration　reduction　was　better　when　the　millisecond　time　between　holes　was　42　ms.　The　result　shows　that　the　millisecond　time,　given　by　the　slope　stability　coefficient,　is　consistent　with　the　simulated　and　experimental　results,　which　provides　a　reference　for　related　research　on　vibration　reduction　of　millisecond　hole-by-hole　blasting.　©　2019,　Editorial　Staff　of　EXPLOSION　AND　SHOCK　WAVES.　All　right　reserved.