One-pot　synergistic/cascade　reactions　represent　a　promising　direction　for　future　catalysis.　In　particular,　the　use　of　solar　light　to　initiate　the　synergistic/cascade　reactions　in　one　pot　has　attracted　increasing　attention,　with　the　aim　of　developing　renewable　energy–based　processes.　Metal–organic　frameworks　(MOFs),　are　considered　to　be　a　promising　type　of　multifunctional　catalysts　for　light-initiated　synergistic/cascade　catalysis,　due　to　their　excellent　photoactive　activity　and　unique　structural　characteristics,　which　enable　the　incorporation　of　functionally　different　catalytic　active　sites　to　work　in　concert.　Herein,　some　recent　developments　on　using　MOFs　as　multifunctional　catalysts　for　light-initiated　one-pot　synergistic/cascade　reactions　are　summarized.　This　review　starts　with　general　background　information　on　synergistic/cascade　catalysis　and　the　possibility　of　using　MOFs　as　multifunctional　catalysts　for　light-initiated　synergistic/cascade　reactions.　Then　some　examples　of　designing　and　fabricating　of　multifunctional　MOFs,　including　single　MOFs,　doped　MOFs,　and　metal　nanoparticles　(MNPs)/MOFs,　for　a　variety　of　light-initiated　one-pot　synergistic/cascade　reactions　are　demonstrated.　Finally,　the　challenges　and　the　perspective　of　the　development　of　multifunctional　MOFs　for　light-induced　one-pot　synergistic/cascade　reactions　are　addressed.　It　is　hoped　that　this　review　can　stimulate　future　research　on　the　designing　and　developing　of　more　smart　multifunctional　MOFs　for　light-initiated　one-pot　synergistic/cascade　reactions.　©　2020　Wiley-VCH　GmbH