Dual activated NIR-II fluorescence and photoacoustic imaging-guided cancer chemo-radiotherapy using hybrid plasmonic-fluorescent assemblies - Details

author：

Indexed by：

Scopus CSCD

Abstract：

Multimodal　imaging　in　the　second　near-infrared　window　(NIR-II)　guided　cancer　therapy　is　a　highly　precise　and　efficient　cancer　theranostic　strategy.　However,　it　is　still　a　challenge　to　develop　activated　NIR-II　optical　imaging　and　therapy　agents.　In　this　study,　we　develop　a　pH-responsive　hybrid　plasmonic-fluorescent　vesicle　by　self-assembly　of　amphiphilic　plasmonic　nanogapped　gold　nanorod　(AuNNR)　and　fluorescent　down-conversion　nanoparticles　(DCNP)　(AuNNR-DCNP　Ve),　showing　remarkable　and　activated　NIR-II　fluorescence　(FL)/NIR-II　photoacoustic　(PA)　imaging　performances.　The　hybrid　vesicle　also　exhibited　superior　loading　capacity　of　doxorubicin　as　a　superior　drug　carrier　and　efficient　radiosensitizer　for　X-ray-induced　radiotherapy.　Interestingly,　the　accumulated　hybrid　AuNNR-DCNP　Ve　in　the　tumor　resulted　in　a　recovery　of　NIR-II　FL　imaging　signal　and　a　variation　in　NIR-II　PA　imaging　signal.　Dual　activated　NIR-II　PA　and　FL　imaging　of　the　hybrid　vesicle　could　trace　drug　release　and　precisely　guided　cancer　radiotherapy　to　ultimately　reduce　the　side　effects　to　healthy　tissue.[Figure　not　available:　see　fulltext.].　©　2020,　Tsinghua　University　Press　and　Springer-Verlag　GmbH　Germany,　part　of　Springer　Nature.

Keyword：

fluorescence imaging; photoacoustic imaging; plasmonic gold nanovesicle; radiotherapy; second near-infrared window (NIR-II)

Community：

[ 1 ] [Chen, T.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 2 ] [Su, L.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 3 ] [Ge, X.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 4 ] [Zhang, W.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 5 ] [Li, Q.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 6 ] [Zhang, X.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 7 ] [Ye, J.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 8 ] [Lin, L.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 9 ] [Song, J.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 10 ] [Yang, H.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350116, China

Reprint 's Address：

[Chen, T.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou UniversityChina

Email：

jibinsong@fzu.edu.cn

Show more details

Related Keywords：

Source ：

Nano Research

ISSN： 1998-0124

Year： 2020

Issue： 12

Volume： 13

Page： 3268-3277

8 . 8 9 7

JCR@2020

9 . 6 0 0

JCR@2023

ESI HC Threshold：115

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count： 0

SCOPUS Cited Count： 52

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 2

Affiliated Colleges：

Get Fulltext

DOI Library Discovery Baidu Scholar Search SCOPUS

Type
Departments

All Years Choose Year From to