A　kind　of　“intelligent”　antibacterial　dressing–A-HA/HA-ADH/SS　hydrogel　was　in　situ　formed　quickly　via　dynamic　covalent　bonds　cross-linking　between　aldehyde　hyaluronic　acid　(A-HA),　adipic　acid　dihydrazide　graft　hyaluronic　acid　(HA-ADH)　and　sisomicin　sulfate　(SS).　FT-IR,　SEM　and　rheological　results　displayed　that　the　hydrogels　were　successfully　prepared.　The　hydrogels　had　good　optical　transmittance,　injectability,　self-healing　ability,　cytocompatibility,　antioxidant　activity　and　hemostatic　performance　which　were　beneficial　to　observe　the　wound　healing　condition　and　provide　a　good　healing　environment　for　wounds.　In　addition,　the　hydrogels　showed　a　pH-　and　HAase-　dependent　degradability,　which　allowed　them　to　release　more　SS　at　infected　wound　and　then　exert　on-demand　and　sustained　antibacterial　effect　against　S.　aureus　and　E.　coli.　The　results　of　wound　healing　and　histological　examination　revealed　that　these　hydrogels　have　a　good　therapeutic　effect　in　the　full-thickness　mouse　skin　defect　wound.　Thus,　the　hydrogels　are　expected　to　be　used　as　potential　wound　dressings　to　improve　wound　healing.　©　2020　Elsevier　B.V.