A near-infrared turn-on fluorescence probe for glutathione detection based on nanocomposites of semiconducting polymer dots and MnO2 nanosheets - Details

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Abstract：

Fluorescence　biosensors　that　enable　highly　sensitive　detection　of　glutathione　(GSH)　are　in　great　demand　for　various　biological　investigations　and　early　disease　diagnoses.　Here,　we　report　a　turn-on　fluorescence　nanoplatform　based　on　fluorescent　semiconducting　polymer　nanoparticle@MnO2　nanosheets　(P-dot@MnO2)　nanocomposites　for　rapid　homogeneous　determination　of　GSH.　The　near-infrared　(NIR)　fluorescent　P-dots　were　prepared　by　doping　NIR　dyes　into　polymer　matrix　and　then　encompassed　by　MnO2,　which　resulted　in　a　remarkable　fluorescence　quenching.　Owing　to　the　selective　decomposition　of　MnO2　by　GSH,　the　fluorescence　recovery　was　achieved　in　the　presence　of　GSH.　On　the　basis　of　the　target-induced　turn-on　fluorescence　response,　the　developed　nanoplatform　can　readily　detect　GSH　with　a　high　sensitivity　up　to　0.26 μM,　as　well　as　a　superior　specificity.　Furthermore,　it　was　successfully　applied　in　monitoring　the　intracellular　GSH　in　living　cells,　revealing　its　great　potential　in　biomedical　applications.　[Figure　not　available:　see　fulltext.]　©　2020,　Springer-Verlag　GmbH　Germany,　part　of　Springer　Nature.

Keyword：

Fluorescence resonance energy transfer; Fluorescent polymer dots; Manganese dioxide nanosheets; Nanoplatform

Community：

[ 1 ] [Zheng, C.]College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
[ 2 ] [Ding, L.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian 350116, China
[ 3 ] [Ding, L.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, China
[ 4 ] [Wu, Y.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian 350116, China
[ 5 ] [Wu, Y.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, China
[ 6 ] [Tan, X.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, China
[ 7 ] [Zeng, Y.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian 350116, China
[ 8 ] [Zeng, Y.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, China
[ 9 ] [Zeng, Y.]Liver Disease Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China
[ 10 ] [Zhang, X.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian 350116, China
[ 11 ] [Zhang, X.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, China
[ 12 ] [Liu, X.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian 350116, China
[ 13 ] [Liu, X.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, China
[ 14 ] [Liu, J.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian 350116, China
[ 15 ] [Liu, J.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, China
[ 16 ] [Liu, J.]Liver Disease Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China

Reprint 's Address：

[Zhang, X.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Liver Disease Center, The First Affiliated Hospital of Fujian Medical UniversityChina

Email：

xiaolongdo@gmail.com

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Source ：

Analytical and Bioanalytical Chemistry

ISSN： 1618-2642

Year： 2020

Issue： 29

Volume： 412

Page： 8167-8176

4 . 1 4 2

JCR@2020

3 . 8 0 0

JCR@2023

ESI HC Threshold：160

JCR Journal Grade：2

CAS Journal Grade：2

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 13

ESI Highly Cited Papers on the List： 0 Unfold All

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Chinese Cited Count：

30 Days PV： 0

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