This　paper　proposes　a　highly　efficient　antibacterial　system　based　on　a　synergistic　combination　of　photodynamic　therapy,　photothermal　therapy,　and　chemotherapy.　Chitosan　oligosaccharide　functionalized　graphene　quantum　dots　(GQDs-COS)　with　short-term　exposure　to　450　nm　visible　light　are　used　to　promote　rapid　healing　in　bacteria-infected　wounds.　The　GQDs　undergo　strong　photochemical　transformation　to　rapidly　produce　radical　oxygen　species　and　heat　under　light　illumination,　while　the　COS　has　an　innate　antimicrobial　ability.　Moreover,　the　positively　charged　GQDs-COS　can　easily　capture　bacteria　via　electrostatic　interactions　and　kill　Gram-positive　and　Gram-negative　bacteria　by　multivalent　interactions　and　synergistic　effects.　The　antibacterial　action　of　this　nanocomposite　causes　irreversible　damage　to　outer　and　inner　bacterial　membranes,　resulting　in　cytoplasm　leakage　and　death.　The　system　has　good　hemocompatibility　and　low　cytotoxicity　and　can　improve　the　healing　of　infected　wounds,　as　demonstrated　by　the　examination　of　pathological　tissue　sections　and　inflammatory　markers.　These　results　suggest　that　GQDs　anchored　with　bioactive　molecules　are　a　potential　photo-activated　antimicrobial　strategy　for　anti-infective　therapy.　©　2020　American　Chemical　Society.