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author：

Zhang, S. (Zhang, S..) [1] | Chen, C. (Chen, C..) [2] | Xue, C. (Xue, C..) [3] | Chang, D. (Chang, D..) [4] | Xu, H. (Xu, H..) [5] | Salena, B.J. (Salena, B.J..) [6] | Li, Y. (Li, Y..) [7] | Wu, Z.-S. (Wu, Z.-S..) [8]

Indexed by：

Scopus

Abstract：

Herein,　we　report　on　the　design　of　a　programmable　DNA　ribbon　using　long-chain　DNA　molecules　with　a　user-defined　repetitive　padlock　sequence.　The　DNA　ribbon　can　be　further　combined　with　gold　nanoparticles　(AuNPs)　to　create　a　composite　nanomaterial　that　contains　an　AuNP　core　and　a　high-density　DNA　crown　carrying　a　cancer-cell-targeting　DNA　aptamer,　a　fluorescent　tag　for　location　tracking,　and　a　cell-killing　drug.　This　composite　material　can　be　efficiently　internalized　by　cancer　cells　and　its　cellular　location　can　be　tracked　by　fluorescence　imaging.　The　system　offers　several　attractive　characteristics,　including　simple　design,　tunable　DNA　crown,　high　drug-loading　capacity,　selective　cell　targeting,　and　pH-sensitive　drug　release.　These　features　make　such　a　material　a　promising　therapeutic　agent.　©　2020　Wiley-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim

Keyword：

aptamers; drug delivery; gold nanoparticles; nucleic acids; self-assembly

Community：

  • [ 1 ] [Zhang, S.]Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis, Chemoprevention and Chemotherapy, National & Local Joint Biomedical Engineering Research Center on, Photodynamic Technologies, Pharmaceutical Photocatalysis of State Key Laboratory of, Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
  • [ 2 ] [Chen, C.]Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis, Chemoprevention and Chemotherapy, National & Local Joint Biomedical Engineering Research Center on, Photodynamic Technologies, Pharmaceutical Photocatalysis of State Key Laboratory of, Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
  • [ 3 ] [Xue, C.]Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis, Chemoprevention and Chemotherapy, National & Local Joint Biomedical Engineering Research Center on, Photodynamic Technologies, Pharmaceutical Photocatalysis of State Key Laboratory of, Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
  • [ 4 ] [Chang, D.]Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main Street West, Hamilton, ON L8S4K1, Canada
  • [ 5 ] [Xu, H.]Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis, Chemoprevention and Chemotherapy, National & Local Joint Biomedical Engineering Research Center on, Photodynamic Technologies, Pharmaceutical Photocatalysis of State Key Laboratory of, Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
  • [ 6 ] [Salena, B.J.]Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON L8S4K1, Canada
  • [ 7 ] [Li, Y.]Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main Street West, Hamilton, ON L8S4K1, Canada
  • [ 8 ] [Wu, Z.-S.]Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis, Chemoprevention and Chemotherapy, National & Local Joint Biomedical Engineering Research Center on, Photodynamic Technologies, Pharmaceutical Photocatalysis of State Key Laboratory of, Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350002, China

Reprint 's Address：

  • [Wu, Z.-S.]Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis, Chemoprevention and Chemotherapy, National & Local Joint Biomedical Engineering Research Center on, Photodynamic Technologies, Pharmaceutical Photocatalysis of State Key Laboratory of, Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main Street West, China

Email：


zswu@fzu.edu.cn
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Source ：

Angewandte Chemie - International Edition

ISSN： 1433-7851

Year： 2020

Issue： 34

Volume： 59

Page： 14584-14592

1 5 . 3 3 6

JCR@2020

1 6 . 1 0 0

JCR@2023

ESI HC Threshold：160

JCR Journal Grade：1

CAS Journal Grade：2

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 69

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 2

Affiliated Colleges：

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